In Oregon, the incidence of meningococcal disease has increased substantially, more than doubling from 2.2 cases per 100,000 persons in 1992 to 4.6 per 100,000 in 1994--the highest incidence in Oregon since 1943. This incidence was almost fivefold higher than recent estimates for the United States during 1989-1991 (approximately one case per 100,000 persons annually) (1). This report describes ...

651. Epidemiology of Serogroup B Meningococcal Outbreaks and Interim Guidelines for the Use of an Unlicensed Serogroup B Vaccine Under a CDCSponsored IND for the Control of Outbreaks in Organizational Settings Sarah Meyer, MD, MPH; Jessica Macneil, MPH; Amy Blain, MPH; Thomas a. Clark, MD, MPH; Amanda Cohn, MD; For the Meningococcal Outbreak Work Group,; Meningitis and Vaccine Preventable Disea...

background: neisseria meninigitidis is one of the most frequently encountered microorganisms associated with central nervous system infections. the aim of this study was to evaluate a pcr-based assay for specific and rapid detection of n. meninigitidis in csf specimens.   methods : since april 2002 to july 2006, 130 csf specimens were collected from patients suspected of having bacterial mening...

C with other infections, such as yellow fever or malaria, awareness of the potential for travelers to contract meningococcal disease is low. Global disease incidence rates, however, may be as high as 1,000/100,000 population in the ‘‘meningitis belt’’ of sub-Saharan Africa and are generally between 100 and 800/100,000 population during epidemics in Africa.1,2 In the United States, the annual in...

The epidemiology of meningococcal disease in England and Wales has been subject to regular periodic review and comment. Seasonal and period trends in incidence based upon laboratory confirmed reports and oYcial notifications have been documented for all meningococcal disease and for major serogroups and sub-types. The disease is noted to be commoner in the winter months and among younger age gr...

BACKGROUND Diagnosis of meningococcal disease relies on recognition of clinical signs and symptoms that are notoriously non-specific, variable, and often absent in the early stages of the disease. Loop-mediated isothermal amplification (LAMP) has previously been shown to be fast and effective for the molecular detection of meningococcal DNA in clinical specimens. We aimed to assess the diagnost...

Meningococcal infections can be associated with abnormalities of the complement system, which contains 5 terminal complement proteins. Furthermore, deficiencies in 1 of these 5, complement component 7 (C7), leads to the loss of complement lytic function, and affected patients show increased susceptibility to recurrent meningococcal meningitis and systemic Neisseria gonorrhoeae infection. In Sep...

The frequency of complement deficiency in 176 of 7,732 patients with meningococcal disease in the Netherlands from 1959 through 1992 was assessed. Complement deficiency was found in six patients (3%): 3 (7%) of the patients with Neisseria meningitidis serogroup C disease, 1 (2%) of the patients with N. meningitidis serogroup A disease, and 2 (33%) of the patients with infections due to uncommon...