a rapid isocratic method of high performance liquid chromatography system (hplc) with a glassy carbon working electrode of electrochemical detector is set up for quantitative detection of  trace amount of nitrite ion (no2¯) in aqueous protein containing cell lysate, cell media, plasma, serum, urine and other body fluids. the solid extraction  reversed phase cartridges (sep-pak) are used for dep...

The high lethality in peritonitis and the lack of data on role various NO-synthase isoforms its pathogenesis suggests advisability research to study effects (NOS) inhibitors.

Cereal β-glucan is a type of valuable dietary fiber that mainly exists in the aleurone, subaleurone, and endosperm some cereal grains. β-Glucan acknowledged as functional food ingredient owing to its multiple health benefits, including prevention diabetes, reduction incidence cardiovascular disease, antitumor effects, antioxidant activities, immunostimulation. It well documented cellulose synth...

Cyanobacteria are considered a promising source for new ‎pharmaceutical lead compounds and a large number of chemically diverse and ‎bioactive metabolites have been obtained from cyanobacteria. Despite of ‎several worldwide studies on prevalence of NRPSs and PKSs among the ‎cyanobacteria, none of them included Iranian cyanobacteria of Kermanshah ‎province. Therefore, the aim of this study was t...

Site-directed mutagenesis (SDM) as a powerful technique was used to change two important and conserved amino acids in 5-enolpyruvylshikimate 3- phosphate synthase (EPSPS) gene of E. coli. The mutations changed glycine 96 to alanine and alanine 183 to threonine. These two amino acids are very important for intraction of the wide spectrum herbicide, glyphosate, to EPSP synthase enzymes. By design...

Objective(s): Investigation of acute effect on cellular bioenergetics provides the opportunity to characterize the possible adverse effects of drugs more comprehensively. This study aimed to investigate the changes in biochemical and biophysical properties of heart mitochondria induced by captopril and nifedipine antihypertensive treatment. Materials and Methods: Male, 12-week-old Wistar rats i...

To replace and avoid synthetic chemicals toxicity, there is a growing interest in the investigation of natural products from plant origin for the discovery of active compounds with antimicrobial properties. This work was devoted to determine chemical composition and antimicrobial properties of the EO of M. piperita harvested in the garden of the National Institute of Medicinal and Aromatic Plan...

abstract background: nitric oxide (no) is a molecule that incorporates in many physiological processes of female reproductive system. recent studies suggested the possible role of endothelial isoform of nitric oxide synthase (enos) enzyme in female infertility. objective: the aim of this study is to evaluate the expression of endothelial nitric oxide synthase in endometrial tissue of women with...

various polymorphisms on endothelial nitric oxide synthase (enos) gene cause reduced production of no, the endothelial relaxing factor, and may accelerate the process of atherosclerosis. the study designed to investigate the frequency of t-786c polymorphism of the enos gene in patients suffering from coronary artery disease (cad) in north-west of iran. one hundred twenty subjects including 60 p...