Azathioprine is a thiopurine prodrug clinically used for immunosuppression in the treatment of inflammatory diseases and in pharmacological regimens of organ transplantations. Its pharmacological action is based on the release of 6-mercaptopurine, but the biochemical processes underlying this biotransformation have remained obscure. In this investigation, human glutathione transferases (GSTs) f...

DBA/2 mice and BALB/c x DBA/2 F( mice were inoculated i.p. with 1 x 105 L1210 leukemia cells on Day 0. Beginning with Day 1 following inoculation, the animals were given injec tions of 6-mercaptopurine riboside (200 mg/kg i.p.) once daily for 5 consecutive days in combination with a single s.c. injec tion of levamisole (LMS) (10 mg/kg). In DBA/2 mice, a marked decrease in the total peritoneal c...

By JANINE ANDRI -SCHWARTL I HE REJECTION of a skin homograft by the rabbit is accompanied by the proliferation of large, basophilic cells (hemocytoblasts) in its lymphoid system.1-2 These cells first appear in the lymph node contiguous to the homograft; later, they are found in regional and distant lymphatic structures, but they are always most prominent in the lymph node draining the homograft...