To the Editor: The QT-RR interval relationship is too complex to be described by using simple correction factors. Because the regulatory and commercial impact of even minor errors in drug studies can be far reaching, these correction factors have come under scrutiny. The letter by Dr Barbey, “Vardenafil-Associated QTc Changes: Not Merely a Normal Autonomic Process,” emphasizes the important poi...

Hurd's (1995) model of a discrete action-response game in which the interests of signallers and receivers connict, is extended to address games in which, as well as signal cost varying with signaller quality, the value of an observer's response to a signal is also dependent on signaller quality. It is shown that non-handicap signalling equilibria exist for such a model. Grafen's (1990) proof of...

Recent years have witnessed a resurgence of classic tensions concerning the fundamental nature of human knowledge and the processes underlying its acquisition. This tension, especially evident in research on the acquisition of words and concepts, arises when researchers pit one type of content against another (perceptual versus conceptual) and one type of process against another (associative ve...

The focus of this review is on literature that deals with the effects of lactoferrin on the brain. This intriguing peptide has a large array of biological effects. This peptide is considered as part of the innate immune system with ipso facto defense properties. Produced from degranulation of neutrophils and other cells, it travels through circulation and crosses the blood brain barrier. Lactof...