background & objectives:  cd10 is a cell surface enzyme with metalloendopeptidase activity, also known as common acute lymphoblastic leukaemia antigen, which mainly serves as a marker for acute lymphoblastic leukemia (all). to date and to the best of our knowledge, only few comparative immunohistochemical studies have assessed cd10 expression in cutaneous epithelial neoplasms. our goal was ...

alpha thalassemia (α-thal) is relatively common worldwide. most carriers are defective in either one or two alpha globin genes out of four functional ones, with deletions being more common than point mutations. the hematologic features are very important for the selection of the appropriate molecular tests while determining the genotype. the aim of this study was to compare hematologic features...

multipotent mesenchymal stromal cells or mesenchymal stem cells (mscs) are mainly isolated from bone marrow or fat tissue. because of their potential of multilineage differentiation towards bone, cartilage and fat tissue, they were initially evaluated to develop innovative strategies for tissue engineering applications. more recently, they have gained interest based on their immunomodulatory pr...

shiga toxins (stxs) are bacterial virulence factors produced by shigella dysenteriae serotype 1 and escherichia coli strains. stxs are critical factors for the development of diseases such as severe bloody diarrhea and hemolytic uremic syndrome. additionally, stxs trigger the secretion of pro- inflammatory cytokines and chemokines, particularly in monocytes or macrophages. the inflammatory cyto...

spermatogonial stem cells (sscs) maintain spermatogenesis throughout life in the male. maintenance of sscs and induction of spermiogenesis in vitro may provide a therapeutic strategy to treat male infertility. this study investigated in vitro differentiation of mouse sscs in presence or absence of sertoli cells, hormones and vitamins. spermatogonial populations were enriched from testes of 4-6 ...

objective: by date investigations have indicated the presence of stem cells within the pulp tissue of both temporary and permanent human teeth. in the present study, these stem cells were compared in terms of their growth kinetics and culture requirements. materials and methods: stem cells within the pulp of the human third molar (permanent tooth) and the deciduous incisor (temporary tooth) wer...

objective(s)para-nonylphenol (p-np) is used in many industries and our previous study showed that p-np causes a reduction in rats bone marrow mesenchymal stem cells (mscs) viability. the aim of this study was to investigate the effect of p-np on osteogenic differentiation of mscs.materials and methodsmscs were isolated and expanded to 3rd passage, then cultured in dmem supplemented with osteoge...

objective(s):leptin is a novel and interesting hormone for anyone trying to lose weight, but its effects on male gonad structure in longitudinal study is unknown. the present study was designed to explore morphometrical changes of mouse testicular tissue after long-term administration of leptin. materials and methods:thirty healthy mature male mice were randomly assigned to either control (n=15...

background: embryonic stem (es) cells are pluripotent cells conventionally isolated from early embryos. studies have shown that es cells serve as a practical model for biomedical studies. objective: the aim of the present study was to optimize culture conditions for establishment of es-like colonies from nmri mouse blastocysts as well as 2-cell stage embryos. materials and methods: both expande...

background: creation of artificial gametes may provide a universal solution for these patients of lacking gametes. stem cell technology may provide a way to obtain fully functional gametes. retinoic acid (ra) can initiate meiosis. several studies have demonstrated that ra can promote sperm cells differentiation from mouse embryonic stem cells (mescs) and other cells from human embryonic stem ce...