Over a 27-year period there were 15 patients treated at the University of Michigan Medical center for carcinosarcomas or mixed mesodermal tumors of the ovary. Overall median survival was 11 months. Median survival was 4 months in patients with carcinosarcomas and 13 months in patients with mixed mesodermal tumors (P = 0.066). Patients with a chondrosarcomatous element had a significantly longer...

Pulmonary blastomas are extremely rare subpleural tumours consisting of relatively welldifferentiated branched tubular glands which resemble fetal lung tissue embedded in a malignant mesodermal stroma. The previous 13 established cases reported up to June 1969 are now supplemented by a fourteenth. The patient was a 32-year-old man who developed acute pain in the right chest followed by a haemor...

This paper reviews work with cell lineage labels and cell-type specific markers in the analysis of inductive interactions in early amphibian development. Our results provide clear evidence for the existence of three such interactions. Mesodermal induction occurs in the early blastula and results from the action of vegetal pole cells on the animal hemisphere. At least two mesodermal rudiments ar...

Using time-lapse cinemicrography and scanning electron microscopy, we have shown that normal Rana embryos and gastrulating hybrid embryos have extracellular fibrils on the inner surface of the ectodermal layer. These fibrils are absent prior to gastrulation and appear in increasing numbers during gastrulation. They can also be deposited in vitro where they condition substrata in such a way that...

In vertebrates, PDGFA and its receptor, PDGFRalpha, are expressed in the early embryo. Impairing their function causes an array of developmental defects, but the underlying target processes that are directly controlled by these factors are not well known. We show that in the Xenopus gastrula, PDGFA/PDGFRalpha signaling is required for the directional migration of mesodermal cells on the extrace...

a 22-year-old man presented with exertional dyspnea commencing one month prior to his admission. echocardiography revealed a non-homogenous mass, and the pathology examination of the pericardial biopsy was compatible with angiosarcoma.

The results of previous studies on the effects of nicotinamide levels on chick limb mesodermal cell expression have indicated that there may exist a metabolic gradient situated radially across the limb which has a controlling influence on whether a limb cell will differentiate into either a myogenic or chondrogenic phenotype. This study investigates the possible role of the vascular pattern in ...

Our understanding of how mesodermal tissue is formed has been limited by the absence of specific and reliable markers of early mesoderm commitment. We report that mesoderm commitment from human embryonic stem cells (hESCs) is initiated by epithelial-to-mesenchymal transition (EMT) as shown by gene expression profiling and by reciprocal changes in expression of the cell surface proteins, EpCAM/C...