aim and background: meta-cognitive therapy is based on the principle that meta-cognitive is very important for understanding the way of cognition function and the way of producing our conscious experience about ourselves and the world around us. in this research it has been tried to study the effectiveness of this kind of treatment in improving depression patients. methods and materials: this c...

Activation of the c-Met receptor promotes intracellular signaling that is often synergistic, complementary, and, at times, redundant to that of other receptor tyrosine kinases (RTKs). It is therefore not surprising that the cellular processes induced by c-Met share many common features with other RTKs, i.e., anti-apoptosis, proliferation, and angiogenesis. However, 2 important phenotypes appear...

Receptor tyrosine kinases play important roles in the biology of many tumor cell types. In approximately 10% of non-small cell lung cancer (NSCLC) patients mutational activation of the epidermal growth factor receptor (EGFR) results in tumor cells that are exquisitely addicted to signaling by this receptor. (1) Thus expression of mutant active EGFR but in general not wild-type EGFR predisposes ...

• Rd is endowed with the standard inner product (·, ·) and Euclidean norm ‖ · ‖. • Md×d(R) denotes the space of n× n real matrices. • When Rd = E ⊕ F is a splitting of Rd into complementary subspaces, we let πE//F denote the projection onto E, parallel to F ; that is, the range of πE//F is E, πE//F ◦ πE//F = πE//F , and kerπE//F = F . • For a subspace E ⊂ Rd, let πE denote the orthogonal projec...

Feeding metabolism and the activation of myogenic progenitor cells were investigated in the fast myotomal muscle of the sub-Antarctic fish Hapagifer bispinis acclimatized to either simulated summer (10 degrees C; 18 h:6 h light:dark) or simulated winter (5 degrees C; 6 h:18 h light:dark) conditions. Ingestion of a single meal equivalent to 10% and 15% of body mass in simulated winter and summer...

BACKGROUND Meningiomas show high recurrence rates even after curative tumor removal. The invasiveness of meningiomas may contribute to their high recurrence rates. Recently, c-MET and hepatocyte growth factor (HGF) have been reported to be involved in cancer invasion. METHODS We examined the immunohistochemical expression of c-MET and HGF in 100 cases of patients with meningiomas who have und...

The mammary gland is a renewing tissue in which morphogenetic processes and differentiation occur cyclically during the menstrual cycle, pregnancy and lactation. These events have been shown to be dependent upon epithelial-mesenchymal interactions. Studies of the effects of individual factors, their cellular source and their target cell populations in the different developmental stages of the m...

Monoclonal antibodies can be seen as valuable tools for many aspects of basic as well as applied sciences. In the case of MET/HGFR, they allowed the identification of truncated isoforms of the receptor, as well as the dissection of different epitopes, establishing structure-function relationships. Antibodies directed against MET extracellular domain were found to be full or partial receptor ago...

c-Met, a type of receptor tyrosine kinase, may be significantly associated with the progression of hepatocellular carcinoma (HCC). In addition, des-γ-carboxyprothrombin (DCP) has been found to interact with c-Met and activate HCC cell growth. Therefore, the functional inhibition of c-Met expressed on HCC cells should arrest HCC cell growth. The present study found that the c-Met inhibitor SU112...