Background: Obesity in children and adolescents has increased exponentially around the world. Furthermore, COVID-19 pandemic led to a higher pediatric obesity rate. The excess adipose tissue generates dysregulation of adiponectin, ghrelin, leptin, among others. Metabolic alterations can develop cardiovascular disease, dyslipidemias, arterial hypertension, type 2 diabetes mellitus, nonalcoholic ...

Nowadays, the one-year survival rate of liver transplant recipients is 80-90 %. In long term after surgery, there are increased risks death compared with general population. At same time, in structure recipients, extrahepatic causes prevail over graft pathology. Cancers, cardiovascular diseases, infections, metabolic disorders, and kidney disease key factors that negatively affect long-term out...

The Liver and Hepatobiliary System Metabolic Functions of the Liver Carbohydrate, Protein, and Lipid Metabolism Drug and Hormone Metabolism Bile Production and Cholestasis Cholestasis Bilirubin Elimination Tests of Hepatobiliary Function Disorders of the Liver Hepatitis Acute Viral Hepatitis Chronic Hepatitis Intrahepatic Biliary Disorders Primary Biliary Cirrhosis Primary Sclerosing Cholangiti...

We report the fatal case of neonatal fulminant hepatic failure due to Echovirus infection mimicking an acute metabolic decompensation. After exclusion of several metabolic disorders, the diagnosis of the infectious etiology was confirmed by Polymerase Chain Reaction of Echovirus in liver and spleen tissue. Establishment of etiological diagnosis and exclusion of inherited metabolic disease helpe...

Non-alcoholic fatty liver disease (NAFLD) is associated with the metabolic syndrome characterized by dislipidemia and insulin resistance. We hypothesized that ezetimibe, an inhibitor of NPC1L1, improves these metabolic disorders in Zucker obese fatty rats (ZOF). Ezetimibe significantly lowered total cholesterol and triglycerides in ZOF with prominent reduction in the remnant lipoprotein fractio...

Background: According to high prevalence of renal stone in children, we evaluated the efficacy of treatment with potassium citrate and its correlation with metabolic disorders in children less than two years of age with renal stone and microlithiasis. Methods: In this cross- sectionaly study, 100 patients (less than 2 years old) with renal stone or microlitiasis were evaluated for metabolic di...

STUDIES of haptoglobin, 1-3 group-specific component,3,4 and numerous other products of hepatic synthesis59 have shown that liver homografts permanently retain their original metabolic specificity after transplantation. Consequently, liver transplantation has been regarded for some years4 as a potentially decisive way to treat those inborn errors of metabolism which result partly or completely ...

CONTEXT Suspecting metabolic liver disease in an infant or young child with acute liver failure, and a protocol-based workup for diagnosis is the need of the hour. EVIDENCE ACQUISITION Data over the last 15 years was searched through Pubmed using the keywords Metabolic liver disease and Acute liver failure with emphasis on Indian perspective. Those published in English language where full tex...

Introduction: Liver disease results in complex pathophysiologic disturbances affecting nutrient digestion, absorption, distribution, storage, and use. This article aimed to present a classification of metabolic disturbances in chronic liver disease in children?   Materials and Methods: In this review study databases including proquest, pubmedcentral, scincedirect, ovid, medlineplus were been se...

Peroxisome-proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors that exert in the liver a transcriptional activity regulating a whole spectrum of physiological functions, including cholesterol and bile acid homeostasis, lipid/glucose metabolism, inflammatory responses, regenerative mechanisms, and cell differentiation/proliferation. Dysregulations of the expression, o...