background: beta-adrenergic blocking agents have been broadly used for treatment of many cardiovascular diseases such as arterial hypertension and ischemic heart failure. anti-tumoral, anti-inflammatory and anti-angiogenesis effects of propranolol (a non-selective beta-adrenergic blocker) have been shown. angiogenesis (replenish of the pre-existing vascular networks) plays a critical role in so...

background: integrins are a family of transmembrane proteins that allow communication between the extracellular matrix and the interior of cells. chondrocytes, cells of articular cartilage, express integrins and these molecules appear to have a variety of roles including mechanotransduction. integrins are known to associate with a number of accessory molecules such as cd147 that may act to regu...

there are emerging data on novel tumor markers such as matrix metalloproteinase-2 (mmp-2 or gelatinase-a), which play a key role in tissue invasion and metastasis. we designed an investigation to assess the usefulness of mmp-2 activity as compared to prostate specific antigen (psa) in cancer staging process. we have analyzed the circulating form of mmp-2 in serum samples of patients suffering f...

Metalloproteinases (MPs) play key roles in the responses of cells to their microenvironment. By effecting proteolytic degradation or activation of cell surface and extracellular matrix (ECM) proteins they can modulate both cell-cell and cell-ECM interactions, which influence cell differentiation, migration, proliferation and survival. Both secreted and membranebound forms of metalloproteinases ...

angiotensin ii, the main component of the renin-angiotensin system, is associated with cardiovascular diseases such as hypertension, vascular remodeling and inflammation. remodeling process results from dysregulation of matrix metalloproteinases (mmps) and their tissue inhibitors (timps). mmps are considered as important target genes for angiotensin ii. the aim of this study was to determine th...

Background/aims. Matrix metalloproteinases are major contributors in the breakdown and reconstitution of basement membranes and extracellular matrix in pathophysiological processes. We assessed the expression of matrix metalloproteinases-2 and -9 in intestinal tissue of patients with inflammatory bowel disease. Patients/methods. Resected tissue specimens from patients with Crohn’s disease or ul...

Snake venom is a rich source of metalloproteinase which catalytic mechanism involves a metal after snake bite is an important factor for created disease such as necrosis, heart disease, liver disease. However, this is a very much important protein to design drug for treatment of various diseases. In this study first we compared the amount of essential amino acids Histidine (H), Isoleucine (I), ...

It has previously been shown that BMS-345541 [4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline], a highly-selective inhibitor of IkappaB kinase (IKK), blocks both inflammation and joint destruction in murine collagen-induced arthritis. Although this agent has been shown to inhibit nuclear factor-kappaB-dependent cytokine expression in mice, we examined whether the inhibitor directly ...

SW1353 chondrosarcoma cells cultured in the presence of interleukin-1, concanavalin A or PMA secreted procollagenase 3 (matrix metalloproteinase-13). The enzyme was detected in the culture medium by Western blotting using a specific polyclonal antibody raised against recombinant human procollagenase 3. Oncostatin M enhanced the interleukin-1-induced production of procollagenase 3, whereas inter...

BACKGROUND Previously, we have reported that most, if not all, of the Scyphozoan jellyfish venoms contain multiple components of metalloproteinases, which apparently linked to the venom toxicity. Further, it is also well known that there is a positive correlation between the inflammatory reaction of dermal tissues and their tissue metalloproteinase activity. Based on these, the use of metallopr...