Abstract/ Resumo Behcet's disease (BD) is a multisystem inflammatory disorder characterized by recurrent oral and genital ulcers, skin lesions and uveitis. The nervous system involvement of BD, neuro-Behcet's disease (NBD), is one of the important causes of mortality of the disease. Herein, we present a 29-year-old male with parenchymal NBD who has progressed rapidly and was managed with an unc...

We present a clinical case of acute hepatitis confirmed by liver biopsy. A 24-year-old patient underwent pulse therapy with methylprednisolone due to the onset multiple sclerosis. The enzyme values were within normal range 15 days later. Blood tests revealed development cytolysis syndrome during an unrelated medical examination two months Obvious causes excluded, and biopsy was performed verify...

Etiotropic medicines used at the beginning of pandemic have not shown their effectiveness in reducing duration treatment, development death, as well preventing transition to use mechanical ventilation. To test a new method etiotropic and pathogenetic therapy, we analyzed outcomes complex therapy 30 patients with SARS-CoV-2-associated pneumonia who were treated 1st clinic (advanced for doctors) ...

OBJECTIVES/HYPOTHESIS To evaluate in patients with idiopathic sensorineural hearing loss whether pulse therapy with methylprednisolone leads to better recovery of hearing than traditional oral prednisolone therapy. STUDY DESIGN Randomized controlled trial. METHODS Sixty-seven patients diagnosed with idiopathic sensorineural hearing loss were randomly divided into two groups based on therapy...

To clarify the effectiveness of methylprednisolone pulse therapy on crescentic glomerulonephritis (CresGN), data of 46 patients was retrospectively studied. According to the slope of reciprocals of serum creatinine (s-Cr) the patients were divided into acute and insidious types, and each type was further divided into pulse (P) and conventional (C) therapy groups. In group C, s-Cr improved more ...

Methods At age 7, she developed autoimmune hepatitis. She was diagnosed with lupus nephritis (class II + V) from pathological finding and pulmonary hypertension (PH) at age 10, and treated with immunosuppressive therapy (methylprednisolone pulse therapy, cyclophosphamide pulse therapy and mycophenolate mofetil) and home oxygen therapy at night. Comprehensive examination about PH was carried out...

The aim of the study. To compare effectiveness methylprednisolone, dexamethasone and tocilizumab in patients with severe coronavirus disease. Identify most appropriate treatment option.
 Materials methods. Patients group 1 (n=20) received for anti-inflammatory purposes at a dose 600–800 mg. 2 (n=82) pulse therapy methylprednisolone. 3 6 mg / day. Data are presented as M [25–75]. Statistica...