Background: Pseudomonas aeruginosa is the main pathogen responsible for lung destruction in cystic fibrosis, becoming difficult to eradicate chronic infection. Aims: To describe antibiotic resistance among strains of P.aeruginosa isolated from sputa patients with fibrosis. investigate vivo and vitro expression genes related anaerobic growth. Methods: Sputa (in vivo) vitro) 26 were obtained duri...

Pseudomonas aeruginosa has an extraordinary capacity to evade the activity of antibiotics through a complex interplay of intrinsic and mutation-driven resistance pathways, which are, unfortunately, often additive or synergistic, leading to multidrug (or even pandrug) resistance. However, we show that one of these mechanisms, overexpression of the MexCD-OprJ efflux pump (driven by inactivation o...

BACKGROUND Pseudomonas aeruginosa can become resistant to carbapenems by both intrinsic (mutation-driven) and transferable (β-lactamase-based) mechanisms. Knowledge of the prevalence of these various mechanisms is important in intensive care units (ICUs) in order to define optimal prevention and therapeutic strategies. METHODS A total of 109 imipenem-non-susceptible (MIC >4 mg/L) strains of P...