BACKGROUND Cancer therapy by systemic administration of anticancer drugs, besides the effectiveness shown on cancer cells, demonstrated the side effects and cytotoxicity on normal cells. The targeted drug-carrying nanoparticles may decrease the required drug concentration at the site and the distribution of drugs to normal tissues. Overexpression of major histocompatibility complex class I chai...

MICA and MICB, along with ULPBs, are ligands for the activating receptor NKG2D expressed on NK cells and subsets of T cells in Human. NKG2D ligands are induced by cellular stress and pathogen infections. Their expression is tightly regulated by complex mechanisms both at the mRNA and protein levels. In the case of MICA and MICB, more than 65 and 30 alleles respectively were described with diffe...

MicA is a trans-encoded small non-coding RNA, which downregulates porin-expression in stationary-phase. In this work, we focus on the role of endoribonucleases III and E on Salmonella typhimurium sRNA MicA regulation. RNase III is shown to regulate MicA in a target-coupled way, while RNase E is responsible for the control of free MicA levels in the cell. We purified both Salmonella enzymes and ...

multiple  sclerosis  (ms) is  an  autoimmune  multifactorial  degenerative  disease  with detrimental affliction on central nervous system. mhc class i chain- related genea,b(mica and micb) are nonclassical human leukocyte antigens that can affect on some diseases and also on transplantation. the purpose of this study was to evaluate the mica and micb mrna expression in multiple sclerosis patie...

INTRODUCTION The MHC class i chain-related molecule A (MICA) is a ligand for the natural killer group 2, member D (NKG2D) immunoreceptor activation. The engagement of tumor cell surface MICA to NKG2D stimulates the NK and T cell antitumor immunity. Shedding of MICA by tumor cells facilitates tumor immune evasion, which might partially contribute to tumor progression. MATERIAL AND METHODS Inmu...

We introduce a technique to characterize, in situ, the solid-solid interface formed when a rough metal surface is placed in contact with a smooth mica surface. The technique is based on the use of extended spectral analysis of multiple beam interferometry in conjunction with the surface forces apparatus (SFA). The intensity versus wavelength spectra of light transmitted through the rough metal/...

INTRODUCTION Soluble major histocompatibility complex class I chain-related antigen A (soluble MICA) has recently been considered as an inhibitory molecule which is shed from tumors and protects them against natural killers and some subgroups of T cells' cytolysis. In transplantation, soluble MICA is also a foreign antigenic molecule that can induce allospecific responses. This study aimed to c...

‘‘Adsorption of Polyelectrolytes on Mica’’ sounds like a very specific title and it may be difficult to envision, upon first reflection, why mica deserves a separate chapter in the study of adsorption of polymers on solid substrates. What makes mica such a special substrate? What are the driving forces involved in the adsorption of macromolecules on mica? What mechanisms participate in the adso...

Electric field-induced reorientation of suspended graphitic (GP) flakes and its relaxation back to the original state in a nematic liquid crystal (NLC) host are of interest not only in academia, but also in industrial applications, such as polarizer-free and optical film-free displays, and electro-optic light modulators. As the phenomenon has been demonstrated by thorough observation, the detai...