In mammals, uterine epithelium is remodeled cyclically throughout adult life for pregnancy. Despite the expression of CD9 in the uterine epithelium, its role in maternal reproduction is unclear. Here, we addressed this issue by examining uterine secretions collected from patients undergoing fertility treatment and fertilization-competent Cd9(-/-) mice expressing CD9-GFP in their eggs (Cd9(-/-)T...

Acute uterine inversion is a rare and life-threatening post-partum complication which often occurs when the placenta fails to detach from the uterus after childbirth. The uterine fundus falls into the endometrial cavity and may descend to the cervix (incomplete) or beyond the cervix (complete). Death may occur in 15% of the affected mothers due to pain, blood loss and shock. The shock is often ...

Introduction: The GABAergic system of the brain plays a key role in morphine tolerance and sensitization. As isoniazid is a modulator of the GABAergic system, the present study aims to understand whether isoniazid can influence the induction of tolerance and sensitization to the rewarding effects of morphine.  Methods: The rewarding effects of morphine and isoniazid were assessed using a Condi...

Penelitian ini bertujuan untuk mengetahui fungsi reproduksi dan gambaran histologi organ mencit (Mus musculus) betina pasca pemberian kopi secara oral. Parameter yang diamati adalah berat badan, uterus, panjang siklus estrus, daya fertilisasi, jumlah folikel primer, sekunder, diameter pembuluh darah ovarium, tinggi epitel endometrium, ketebalan endometrium dengan lama selama 21 hari 42 paramete...

Normal endometrial function requires a balance of progesterone (P4) and estrogen (E2) effects. An imbalance caused by increased E2 action and/or decreased P4 action can result in abnormal endometrial proliferation and, ultimately, endometrial adenocarcinoma, the fourth most common cancer in women. We have identified mitogen-inducible gene 6 (Mig-6) as a downstream target of progesterone recepto...

Introduction: Morphine withdrawal syndrome is mediated via several central and peripheral neurological pathways. In the present study we investigated the role of N-methyl-D aspartic acid (NMDA) glutamate receptor on naloxone-induced withdrawal syndrome in morphine-conditioned mice. Materials and Methods: We designed two separate experiments. In experiment one, 30 male NMRI mice were divide...

Abstract Unopposed estradiol and obesity are known risk factors for endometrial adenocarcinoma (EC). Endometrium from women with was found to have an increase in mutations relative tissue normal weight women, indicating DNA damage may be accelerated the setting of obesity. Since is associated high levels insulin anovulatory cycles, we sought mimic these conditions a mouse model. We previously t...

BACKGROUND Endometrium undergoes dramatic growth, breakdown and regeneration throughout reproductive period in mammals. Stem cells have been implicated in the process however their origin, nature, anatomical localization and characterization still remain obscure. Classical concept of presence of stem cells in the basal layer of endometrium was recently challenged when side population and label ...

introduction: there are some evidences that the matricaria recutita extract has sedative effects and relieves symptoms of morphine withdrawal syndrome. symptoms of this syndrome are due to increased expression of fos transcription factor in brain. in this study the effect of chronic hydro alcoholic extract (30 mg/kg) of matricaria recutita on jumping behavior and expression of fos transcription...

Nesfatin-1, an anorexic nucleobindin-2 (NUCB2)-derived hypothalamic peptide, controls appetite and energy metabolism. Recent studies show that nesfatin-1/NUCB2 is expressed not only in the brain but also in gastric and adipose tissues. Thus, we investigated the distributions of nesfatin-1/NUCB2 in various tissues of male and female mice by real-time PCR, western blotting, and immunohistochemica...