نتایج جستجو برای: micelle

تعداد نتایج: 3873  

2014
Ankit Gupta Punit Zadafiya Radhakrishnan Mahalakshmi

Attachment invasion locus (Ail) protein of Yersinia pestis is a crucial outer membrane protein for host invasion and determines bacterial survival within the host. Despite its importance in pathogenicity, surprisingly little is known on Ail biophysical properties. We investigate the contribution of micelle concentrations and interface tryptophans on the Ail β-barrel refolding and unfolding proc...

Journal: :Molecular simulation 2007
D S Bolintineanu A A Langham H T Davis Y N Kaznessis

We have carried out molecular dynamics simulations of the naturally occurring protegrin PG-1 peptide and two of its mutants, PC-9 and PC-13 in the presence of a dodecyl-phosphocholine (DPC) micelle. The effects of mutations that disrupt the β-sheet structure in the case of PC-9 and reduce the charge at the C-terminus in the case of PC-13 are analyzed. It is found that the surface-bound conforma...

2017
Li Lv Chunxia Liu Zhengrong Li Fangming Song Guocheng Li Xingzhen Huang

The purpose of this study was to evaluate the potential of micelle to change the pharmacokinetics of quercetin (QUT), with a primary goal of enhancing its oral bioavailability. QUT-loaded methoxy poly(ethylene glycol)-b-poly(L-lactic acid) micelle (QUT-loaded MPEG-b-PLLA micelle) was prepared by a thin-film hydration method, resulting in a particle size of 88.5 nm. A liquid chromatography tande...

2007
Avinash Bhardwaj Erik Miller Jonathan P. Rothstein

filament stretching extensional rheometer and capillary breakup extensional rheometer are used o measure the extensional rheology of a series of wormlike micelle solutions experiencing a niaxial elongational flow. The experiments are performed using a series of wormlike micelle olutions of both cetylpyridinium chloride and sodium salicylate NaSal in an aqueous sodium hloride solution and cetylt...

2006
A. Ben-Shaul

The elongated shape of linear, worm-like, micelles is among the most common aggregation geometries of amphiphilic molecules in aqueous solutions. The cylindrical body of these uni-dimensional micelles can be regarded as an intermediate packing geometry, of a higher growth dimensionality than that of a spherical micelle and lower than that of a planar bilayer. In all these three canonical struct...

Journal: :Molecules 2013
Francisco Gomes-Neto Ana Paula Valente Fabio C L Almeida

Antimicrobial peptides are highly dynamic entities that acquire structure upon binding to a membrane interface. To better understand the structure and the mechanism for the molecular recognition of dodecylphosphocholine (DPC) micelles by the anticoccidial peptide PW2, we performed molecular dynamics (MD) simulations guided by NMR experimental data, focusing on strategies to explore the transien...

Journal: :The journal of physical chemistry. B 2011
Tanumoy Mondol Priya Rajdev Abhinandan Makhal Samir Kumar Pal

In this contribution, we report studies on the nature of binding of a potent antituberculosis drug, Rifampicin (RF) with a model drug delivery system, sodium dodecyl sulfate (SDS) micelle. Temperature dependent dynamic light scattering (DLS), conductometry, and circular dichroism (CD) spectroscopy have been employed to study the binding interaction of the drug with the micelle. The absorption s...

Journal: :Physical chemistry chemical physics : PCCP 2016
Emmy C Wijaya Frances Separovic Calum J Drummond Tamar L Greaves

Many ionic liquids and low molecular weight polar solvents have been reported to support amphiphile self-assembly, with most of these reported for the first time in the last decade. This phenomenon is attributed to the solvophobic effect (analogous to the hydrophobic effect in water). However, to date there has been no systematic study which evaluates micelle formation in a large library of non...

2013
Jakub MONDEK Miloslav PEKAŘ

Hyaluronan is a biopolymer suitable as a targeting unit in drug delivery systems according to affinity of hyaluronan to CD-44 receptor of cancer cells. We suppose that hyaluronan, when interacts with cationic surfactant, influences hydration of Stern layer of CTAB which affects fluorescence properties of 1-naphthol. We study excited state proton transfer of 1-naphthol in aqueous solution and in...

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