Biomucoadhesive tablets are widely used to formulate topical antifungal drugs for treating acute oral candidiasis. The research focuses on the pharmaco-technological control of certain bio-mucoadhesive tablets containing miconazole nitrate, formulas developed and prepared by the authors based on the original formulas. The analyzed parameters were: macroscopic aspect, physical-chemical (pH) and ...

BACKGROUND/OBJECTIVES Reactive oxygen species (ROS) formation is closely related to miconazole-induced heart dysfunction. Although rhamnetin has antioxidant effects, it remained unknown whether it can protect against miconazole-induced cardiomyocyte apoptosis. Thus, we investigated the effects of rhamnetin on miconazole-stimulated H9c2 cell apoptosis. MATERIALS/METHODS Cell morphology was obs...

The antifungal imidazoles miconazole and ketoconazole inhibit synthesis of essential cell membrane components. Furthermore, miconazole can exert direct physicochemical cell membrane damage at relatively high levels, but ketoconazole cannot. Experiments were designed to explain our previous observation that concentrations of miconazole capable of causing direct membrane damage were no more activ...

background and purpose: candida species are the most common organisms involved in superficial fungal infections, worldwide. although econazole is among the most frequently used topical formulations for the treatment of candidiasis, no information is available regarding the susceptibility profiles of candida species in iran. materials and methods: in vitro susceptibility of 100 clinical candida ...

Miconazole, a potent antifungal agent, labilizes rat liver lysosomes. Its labilizing effect is followed by measuring the release of lysosomal hydrolases, namely, acid phosphatase, beta-glucuronidase, and arylsulfatase A. The effect of miconazole is concentration dependent in the range of 10(-5) to 1.2 x 10(-4) M. However, at higher concentrations, miconazole inhibits enzyme release but does not...

A retrospective review of therapeutic failures of miconazole in three patients is presented. Miconazole, a new imidazole derivative, is a broad-spectrum antifungal agent purportedly effective topically, orally, and parenterally against a number of species of fungi. Three patients with the following culturally proven deep fungal infections were treated with miconazole: (i) destructive arthritis ...

The effect of the antifungal drug miconazole on Ca²⁺ signaling in human breast cancer cells is unknown. This study examined the effect of miconazole on cytosolic free Ca²⁺ concentrations ([Ca²⁺]i) in ZR-75-1 human breast cancer cells. The Ca²⁺-sensitive fluorescent dye fura-2 was used to measure [Ca²⁺]i. Miconazole induced [Ca²⁺]i rises concentration-dependently. The response was reduced by 60%...

Since the publication by GILBERT (3) of the colorimetric method for the determination of nitrate nitrogen, phosphate, and potash in plant juices, several workers have presented criticisms and modifications of this method as applied to nitrates. These include particularly HOLTZ and LARSON (7) and EMMERT (2). Considerable work has been done in this laboratory on this particular determination and ...

Flow-induced dilation of gracilis muscle arterioles was examined in both genders of control rats and rats chronically treated with N(omega)-nitro-L-arginine methyl ester (L-NAME). After L-NAME treatment (4 wk), systolic blood pressure was significantly increased compared with control, whereas the plasma concentration of nitrate/nitrite was significantly reduced. Isolated and pressurized arterio...