Evaluating clustering results is a fundamental task in microarray data analysis, due to the lack of enough biological knowledge to know in advance the true partition of genes. Many quality indexes for gene clustering evaluation have been proposed. A critical issue in this domain is to compare and aggregate quality indexes to select the best clustering algorithm and the optimal parameter setting...

Micro-array Microarrays are microscopic array of single-stranded DNA molecules immobilized on a solid surface by biochemical synthesis also called as DNA chips, gene chips, biochips, DNA microarrays or simply the arrays. Basic idea behind microarray technology is to simultaneously measure the relative expression level of thousands of genes within a particular cell population or tissue. Microarr...

We describe detailed protocols and results with an integrated platform for studying relative transcript expression, including microarray design and fabrication, analysis and calibration algorithms, and high throughput quantitative real-time PCR. This approach optimizes sensitivity and accuracy while controlling the cost of experiments. A high quality cDNA array was fabricated using a restricted...

Tiziana Catarci Dipartimento di Informatica e Sistemistica “A. Ruberti” Universita di Roma “La Sapienza” Via Salaria, 113 00198 Rome, Italy [email protected] Benjamin Habegger Dipartimento di Informatica e Sistemistica “A. Ruberti” Universita di Roma “La Sapienza” Via Salaria, 113 00198 Rome, Italy [email protected] Antonella Poggi Dipartimento di Informatica e Sistemistica “A. Rub...