A challenging task in time-course microarray data analysis is to combine the information provided by multiple time series in order to cluster genes meaningfully. This paper proposes a novel merge method to accomplish this goal obtaining clusters with highly correlated genes. The main idea of the proposed method is to generate a clustering, starting from clusterings created from different time s...

MOTIVATION To resolve the high-dimensionality of the genetic network inference problem in the S-system model, a problem decomposition strategy has been proposed. While this strategy certainly shows promise, it cannot provide a model readily applicable to the computational simulation of the genetic network when the given time-series data contain measurement noise. This is a significant limitatio...

The advances on DNA microarray technologies have enabled researchers to gain hundreds to thousands of gene expression levels. Much effect has been devoted over the past decade to analyze the gene expression data. In this study, flexible neural tree (FNT) model is used for gene regulatory network reconstruction and time-series prediction from gene expression profiling. We use voting strategy and...

Studies on high-throughput global gene expression using microarray technology have generated ever larger amounts of systematic transcriptome data. A major challenge in exploiting these heterogeneous datasets is how to normalize the expression profiles by inter-assay methods. Different non-linear and linear normalization methods have been developed, which essentially rely on the hypothesis that ...

A very promising tool for data mining and bioinformatics is ensemble gene (feature) selection. Ensemble feature selection is the process of performing multiple runs of feature selection and then aggregating the results into a final ranked list. However, a central question of ensemble feature selection is how to aggregate the individual results into a single ranked feature list. There are a numb...

* 0-7803-7952-7/03/$17.00  2003 IEEE. Abstract This paper addresses the problem of inferring topological features of gene regulation networks from data that are likely to be available from current experimental methods, such as DNA microarrays. The proposed method uses neural networks to predict the topology class from histograms of perturbation propagation data. The preliminary results with si...

The classification of different tumor types is of great importance in cancer diagnosis and drug discovery. However, most previous cancer classification studies are clinical-based and have limited diagnostic ability. Cancer classification using gene expression data is known to contain the keys for addressing the fundamental problems relating to cancer diagnosis and drug discovery. The recent adv...

Spectral analysis of DNA microarray gene expressions time series data is important for understanding the regulation of gene expression and gene function of the Plasmodium falciparum in the intraerythrocytic developmental cycle. In this paper, we propose a new strategy to analyze the cell cycle regulation of gene expression profiles based on the combination of singular spectrum analysis (SSA) an...

Microarrays allow monitoring of thousands of genes over time periods. However, due to the low number of time points of the gene expression series, taking the temporal dependences into account when clustering the data is an hard task. Moreover, classes very interesting for the biologist, but sparse with regard to all the other genes, can be completely omitted by the standard approaches. We propo...

Microarrays are important tools in the quest to map the gene regulation networks of cells. A common use of microarrays result in time series pairs that indicates how the output of one gene affects another. Substantial efforts have been made towards identifying pairs of microarray time series that indicate that one gene is a regulator for another. However, most approaches make assumptions about ...