E. Mathilda SJOBERG,*§ Anna BLOM,* Bengt S. LARSSON,t James ALSTON-SMITH,* I Mats SJOQUIST,T and Erik FRIES*¶ *Department of Medical and Physiological Chemistry, University of Uppsala, Biomedical Centre, Box 575, S-751 23 Uppsala, Sweden, tDepartment of Pharmaceutical Biosciences, Division of Toxicology, University of Uppsala, Biomedical Centre, Box 594, S-751 24 Uppsala, Sweden, and tDepartmen...

GUIDELINE RECOMMENDATIONS • We recommend that either synthetic or cellulosic membranes be used for symptomatic intra-dialytic hypotension as synthetic membranes offer no benefit over cellulosic membranes (1C). • We recommend that high-flux membranes be used to remove molecules such as beta-2 microglobulin because they have been shown to achieve lower serum levels (1A). • We suggest there are po...

background : hepatitis includes a wide range of clinical and pathological conditions. the beta-2 microglobulin (ãÿ2m), as part of thehla complex, is responsible for transmission of viral antigens on the surface of liver cells. the purpose of this study is to determine the concentration of salivary ãÿ2m as a marker of viral proliferation in subjects who are hbsag + , hbv dna pcr + compared with ...

beta2-Microglobulin accumulation with resultant tumor formation is a known albeit rare complication of long-term hemodialysis. Although these tumors may occur in various locations, subcutaneous shoulder nodules are very infrequent. We report a patient with end-stage kidney failure who had been on hemodialysis for 16 years and noted left shoulder nodules after initiation of hemodialysis; these n...

The protein β2-microglobulin can aggregate in insoluble amyloid fibrils. By relying on extensive sampling simulations, we study the Pro32 isomerization as a possible triggering factor leading to structural modifications β2-m.

Misfolding intermediates play a key role in defining aberrant protein aggregation and amyloid formation in more than 15 different human diseases. However, their experimental characterization is challenging due to the transient nature and conformational heterogeneity of the involved states. Here, we demonstrate that direct carbon-detected NMR experiments allow observation, assignment, and struct...

The aim of this study is to evaluate connection of plasma level of beta2-microglobulin, C-reactive protein and uric acid as well as sonographic parameters like thickness of synovial membrane, thickness of femoral condylar cartilage and presence of joint effusion and Baker's cysts with bilateral knee pain in dialyzed patients, comparing them with parameters in asymptomatic dialyzed patients. Pla...

The handling of low, middle and high molecular weight markers was examined in seven stable dialysis patients during hemofiltration with different membranes. Four membranes were examined in a randomized, crossover order (polysulfone, polyamide, AN69 polyacrylonitrile, Asahi polyacrylonitrile) by measuring plasma and dialysate concentrations of phosphate, creatinine, vitamin B12, beta 2-microglob...