نتایج جستجو برای: micronuclei assay

تعداد نتایج: 223211  

2018
Jesús Emilo Quintero Ojeda Maribel Aguilar-Medina Vicente Olimón-Andalón Rosa Alicia García Jau Alfredo Ayala Ham José Geovanni Romero Quintana Erika de Lourdes Silva-Benítez Guzmán Sanchez-Schmitz Rosalío Ramos-Payán

Diabetes mellitus (DM) is a metabolic disease characterized by persistent high levels of glucose in plasma. Chronic hyperglycemia is thought to increase oxidative stress and the formation of free radicals that in turn damage cells. Thus, we decided to determine the frequency of nuclear abnormalities in epithelial cells from cheek and tongue mucosa of DM patients with type 1 (DM1, treated only w...

Journal: :Radiation research 2014
Oleksandra V Lyulko Guy Garty Gerhard Randers-Pehrson Helen C Turner Barbara Szolc David J Brenner

The development of, and results from an image analysis system are presented for automated detection and scoring of micronuclei in human peripheral blood lymphocytes. The system is part of the Rapid Automated Biodosimetry Tool, which was developed at the Center for High-Throughput Minimally Invasive Radiation Biodosimetry for rapid radiation dose assessment of many individuals based on single fi...

Journal: :The Journal of bone and joint surgery. British volume 2004
B Daley A T Doherty B Fairman C P Case

Wear debris was extracted from 21 worn hip and knee replacements. Its mutagenic effects were tested on human cells in tissue culture using the micronucleus assay and fluorescent in situ hybridisation. The extracted wear debris increased the level of micronuclei in a linear dose-dependent manner but with a tenfold difference between samples. The concentration of titanium +/- vanadium and alumini...

Journal: :international journal of marine science and engineering 2012
s. eskandari h. mozdarani a. mashinchian moradi m. h. shahhosseiny

crude oil is enriched in polycyclic aromatic hydrocarbons (pahs). many pah analogs have proved to potentially damage dna. dna damage can be assessed using various biomarkers to find out the degree of genotoxicity of pollutants following in vitro exposure. in this research the comet assay and micronucleus (mn) test were used to detect dna damages and cytogenetic changes following crude oil expos...

2013
Ivette Z. Ocampo Kayo Okazaki Daniel P. Vieira

The biological dosimetry is widely used to estimate the absorbed dose in people occupationally or accidentally exposed to the radiation for a better medical treatment, minimizing the harmful effects. Many techniques and methods have been proposed to detect and quantify the radioinduced lesions in genetic material, among them, the micronucleus (MN) assay. In the present study, we proposed an imp...

Journal: :Mutagenesis 2000
H Thierens A Vral R Morthier B Aousalah L De Ridder

A cytogenetic study was performed in lymphocytes of hospital workers occupationally exposed to X- and gamma-rays using the micronucleus centromere assay. A comparison of the data for the exposed group and an age-matched group of non-exposed hospital workers showed a significant (P < 0.05) increase in centromere-positive micronuclei for the radiation workers, while no effect on centromere-negati...

2016
Mansi Patel Priti Mehta Sonal Bakshi Shikha Tewari

The ionizing radiation is a known carcinogen as well as cancer therapeutic agent however, the side effect on normal tissue is a limiting factor and inadequate doses necessitates search for an ideal radioprotective agent. Bamboo species are rich source of antioxidants hence have therapeutic value in many free radical mediated diseases. This is the first report regarding in vitro protective effec...

Journal: :Environmental and experimental botany 2000
Guimarães Domingos Alves Caldini Lobo Lichtenfels Saldiva

Tradescantia pallida cv. purpurea, a popular garden plant in Brazil, was used for the Tradescantia micronucleus (Trad-MCN) assay. In situ monitoring of the genotoxicity of air pollutants was carried out by sentinel approach, using the plant grown in the field or using the plants in pots which were carried to the monitoring sites. Two highly polluted sites, in São Paulo city (Cerqueira Cesar and...

2014
Isheeta Seth Jeffrey L. Schwartz Robert D. Stewart Robert Emery Michael C. Joiner James D. Tucker

Bystander effects have been observed repeatedly in mammalian cells following photon and alpha particle irradiation. However, few studies have been performed to investigate bystander effects arising from neutron irradiation. Here we asked whether neutrons also induce a bystander effect in two normal human lymphoblastoid cell lines. These cells were exposed to fast neutrons produced by targeting ...

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