We present a multipurpose nanomechanical force probe that combines a sideways-mounted elastic cantilever and an optical-lever detection module with automated micropipette manipulation. It allows us to apply and measure compression, stretching, adhesion, and dissociation forces in the horizontal direction while providing a "side view" of ongoing experiments. The integrated micropipette setup fac...

Micropipette recording with juxtacellular Neurobiotin ejection, linked micropipette-microwire recording, and antidromic and orthodromic activation from the ventral tegmental area and locus coeruleus were used to identify hypocretin (Hcrt) cells in anesthetized rats and develop criteria for identification of these cells in unanesthetized, unrestrained animals. We found that Hcrt cells have broad...

The deformability of human platelets has been evaluated by micropipette aspiration. Control discoid platelets were about ten times as resistant to deformation in the micropipette as red blood cells. Under a constant negative pressure of 10 cm H2O, control platelets developed extension lengths of 0.74 +/- 0.1 micron. Prior treatment with vincristine, colchicine, or low temperature, all of which ...

A simple and efficient electrochemical sensor based on a homemade reshaped micropipette tip carbon paste electrode is reported. Molecularly imprinted polymer membranes of graphene oxide polypyrrole are synthesized modified the surface electrode. The merit method evaluated under optimized conditions via differential pulse voltammetrics. prepared exhibits remarkable sensitivity toward dopamine wi...

The key improvement of the corrosion resistance metals requires understanding and resolving electrochemical reactions involved at local scale. Here, we present use pumped-micropipette delivery/substrate collection (Pumped-MD/SC) mode scanning microscopy (SECM) to monitor oxygen reduction reaction (ORR) during an Aluminum (Al) / Copper (Cu) galvanic coupled electrode, a model system copper-rich ...