background: new blood vessels formation is a critical step in tumor progression. vascular density affects the clinical outcome and prognosis of malignant tumors. the aim of this study was to investigate the relation between the vascular endothelial growth factor (vegf) expression and vascular density with the clinical and histopathologic features in oral squamous cell carcinoma (oscc).   method...

AIMS Periductal angiogenesis in ductal carcinoma in situ is associated with an increased risk of subsequently developing a recurrence. This study aimed to (1) identify the relation between periductal and stromal vascularity and recurrence and (2) determine whether thymidine phosphorylase (TP) is associated with angiogenesis or recurrence in ductal carcinoma in situ (DCIS). METHODS Twenty case...

This study provides a method to assess the impact of circulating plasma factors on microvascular integrity by using recently developed microvessel-on-a-chip platform featuring human endothelium that is partly surrounded extracellular matrix. The system high-throughput, which allows parallel analysis organ-level microvessel pathophysiology, including vascular leakage. Ethylenediaminetetraacetic ...

BACKGROUND Neoangiogenesis and the immune response are important mechanisms in metastasis development. AIM to evaluate lymph node reactivity and microvessel density in neck metastasis of occult primary squamous cell carcinoma considering their histological and clinical variables. STUDY DESIGN retrospesctive case-series. METHOD 19 patients with neck metastasis of occult primary squamous ce...

A substantial number of clinical trials using antiangiogenic therapies are ongoing worldwide. How to achieve the maximum benefit from these therapies and how to monitor patient response are of paramount concern to investigators. There are currently no markers of the net angiogenic activity of a tumor available to aid investigators in the design of antiangiogenic treatment schemes. It stands to ...

OBJECTIVE Angiogenesis plays a key role in tumor growth and metastasis. Determination of microvessel density is the most common technique used to evaluate the amount of the intratumoral angiogenesis in breast cancer. We have aimed to investigate the relationship with tumor angiogenesis and prognostic parameters in breast invasive ductal carcinomas. MATERIAL AND METHOD In this study, a total o...

OBJECTIVE To record the correlation between color power Doppler sonographic measurement of breast tumor vasculature and immunohistochemical analysis of microvessel density for the quantitation of angiogenesis. METHODS Women with palpable breast masses scheduled for excision biopsy were scanned with two- and three-dimensional color power Doppler sonography before and after the administration o...

OBJECTIVE The aim of this study is to examine the correlation between tumor angiogenesis and response to preoperative radiotherapy evaluated using 201Tl single photon emission computed tomography (Tl SPECT) in oral cavity squamous cell carcinoma (SCC). METHODS Tl SPECTs before and after preoperative radiotherapy were obtained from 11 patients diagnosed with SCC in oral cavity. Regions of inte...