OBJECTIVES Because there is little information available about blood flow in the voiding cycle of the bladder, we performed a study in which we simultaneously monitored blood flow and intravesical pressure during the micturition cycle in a rat model. METHODS Approximately 300 g male Wistar rats were used in this study. Cystometric studies were performed according to our previous report, and s...

Recent evidence suggests that lower urinary tract functions may be influenced by reproductive status, particularly under pathophysiological conditions. This study used repeated cystometrograms via a transurethral catheter to investigate the influence of estrous stage on micturition thresholds before and after turpentine-induced bladder inflammation in urethane-anesthetized female rats. Whereas ...

Symptoms examined in a level 1 assessment In the report The Standardisation of Terminology of Lower Urinary Tract Function, Abrams at al (2002) divide lower urinary tract symptoms (LUTs) into three groups: ■ Storage symptoms – experienced when urine is stored in the bladder. These include increased daytime frequency and nocturia (Box 1); ■ Voiding symptoms – these include a slow urinary stream,...

Eight patients were evaluated clinically, radiologically, and urodynamically to determine the outcome of continent urinary diversion with ileal neobladder performed to treat the recurrent superficial bladder cancer after cystectomy with subcapsular prostatectomy. The mean age of the patients was 55.3 years. After descending dissection of the urinary bladder without ligation or dissection of San...

This tabulated statement shows the details of five cases operated upon for enlarged prostate by the suprapubic method. Unfortunately, I was unable to get the first case photographed; the remaining four are represented in the picture. It is noteworthy that these old men came in with " trivial " complaints, such as slight difficulty in passing urine, burning micturition, hsematuria or frequency o...

Hypothesis / aims of study Understanding the neurotransmitter mechanisms involved in pudendal nerve inhibition of bladder activity could lead to identify new pharmacological targets for overactive bladder. Currently little is known about the effect of 5-hydroxytryptamine (5-HT) 2 receptor on micturition reflex. This study used methysergide, a non-specific 5-HT2 receptor antagonist, and naloxone...

The functions of the lower urinary tract to store and periodically eliminate urine are regulated by a complex neural control system in the brain and spinal cord that coordinates the activity of the bladder and urethral outlet. Experimental studies in animals indicate that urine storage is modulated by reflex mechanisms in the spinal cord, whereas voiding is mediated by a spinobulbospinal pathwa...

The primary afferent neurotransmitter triggering the spinal micturition reflex after complete spinal cord injury (SCI) in the rat is unknown. Substance P detected immunohistochemically in the sacral parasympathetic nucleus was significantly higher in 12 SCI rats than in 12 spinally intact rats (P = 0.008), suggesting substance P as a plausible candidate for the primary afferent neurotransmitter...

BACKGROUND The purpose of this study was to prove the hypothesis that C-reactive protein (CRP) and nerve growth factor (NGF) may be potential biomarkers for lower urinary tract disorders and may be able to distinguish between micturition dysfunctions of different origin in dogs with spinal cord diseases. NGF- and CRP- concentrations were measured in serum and urine samples using specific ELISA-...

PURPOSE The functions of the lower urinary tract (LUT), such as voiding and storing urine, are dependent on complex central neural networks located in the brain, spinal cord, and peripheral ganglia. Thus, the functions of the LUT are susceptible to various neurologic disorders including spinal cord injury (SCI). SCI at the cervical or thoracic levels disrupts voluntary control of voiding and th...