PURPOSE MicroRNAs (miRNAs) play a global role in regulating gene expression and have important tissue-specific functions. Little is known about their role in the retina. The purpose of this study was to establish the retinal expression of those miRNAs predicted to target genes involved in vision. METHODS miRNAs potentially targeting important "retinal" genes, as defined by expression pattern ...

Abstract Study question Can microRNA expression in blastocoel fluid (BF) predict embryo implantation potential? Summary answer Up-regulation of miR-106, miR-373, miR-301, miR-320 and miR-525-3p represents the molecular signature characterizing embryos with high capability. What is known already The discovery DNA within BF spent culture media, has caused increased interest non-invasive preimplan...

The tonalness spectrum shows the likelihood of a spectral bin being part of a tonal or non-tonal component. It is a non-binary measure based on a set of established spectral features. An easily extensible framework for the computation, selection, and combination of features is introduced. The results are evaluated and compared in two ways. First with a data set of synthetically generated signal...

Response 4: The introduction will be changed to contain: Sussmann et al. 2013 did a similar study on the inter-comparison of methane from MIR and NIR retrievals. They used a Tikhonov-L1 regularized profile retrieval scheme with the standard NDACC retrieval package SFIT2 for the MIR and the standard TCCON retrieval (GFIT) for the NIR spectra. They conclude that the obtainable information from th...

Platinum agents are the backbone of cancer chemotherapy. Recently, we identified and replicated the role of a single nucleotide polymorphism (SNP, rs1649942) in predicting platinum sensitivity both in vitro and in vivo. Using the CEU samples from the International HapMap Project, we found the same SNP to be a master regulator of multiple gene expression phenotypes, prompting us to investigate w...