p2: two SNPs were found significantly associated but only one OR is given. Reply: Sorry for the mistake. Considering the word limit (350) for the abstract, we have omitted the OR and CI values from the abstract in the revised Ms. Query: Abstract p2: it is unclear where TGF-b1 comes from. This gene was not part of this study and hence needs further clarification. Reply: In the objective of the a...

Although the expression of miRNAs has been widely applied to investigate on gonads, role in gonadal development white Pacific shrimp (Litopenaeus vannamei) remains unknown. In this study, we performed high-throughput sequencing identify sex-related microRNAs (miRNAs) that elucidated regulatory mechanisms differentiation L. vannamei. We obtained a total 29,671,557 and 28,526,942 raw reads from o...

Introduction: Emerging evidence indicates that microRNAs play an important role in regulating osteogenic differentiation and osteoblastic bone formation. But, it has been still lack of miRNAs specifically identified in bone specimens from skeletal disorders with reduced bone formation. In the past years, we have screened miRNAs in bone specimens from fractured postmenopausal women across age an...

Despite accumulating data on animal and plant microRNAs and their functions, existing public miRNA resources usually collect miRNAs from a very limited number of species. A lot of microRNAs, including those from model organisms, remain undiscovered. As a result there is a continuous need to search for new microRNAs. We present miRNEST (http://mirnest.amu.edu.pl), a comprehensive database of ani...

Recent work has demonstrated that microRNAs (miRNAs) are involved in critical biological processes by suppressing the translation of coding genes. This work develops an integrated database, miRNAMap, to store the known miRNA genes, the putative miRNA genes, the known miRNA targets and the putative miRNA targets. The known miRNA genes in four mammalian genomes such as human, mouse, rat and dog a...

Pearl millet (Pennisetum glaucum L.) is affected by drought stress, affecting crop productivity and survival. Long non-coding RNAs (lncRNAs) are reported to play a vital role in the response stress. LncRNAs represent major part of non-protein coding present prevalently. These involved various biological processes, which may functionally act as RNA rather than getting transcribed protein. We tar...

MicroRNAs (miRNAs) are endogenous small non-coding RNAs which play a critical role in gene regulation in plants. Pinelliapedatisecta is one of the most important herbs in traditional Chinese medicine, but there are no microRNAs of Pinelliapedatisecta were deposited in miRBase and the research of the related miRNA biological functions is still insufficient. To detect Pinelliapedatisecta miRNAs a...