To investigate the effects ofellagic acid (EA) on the cytotoxicity, B-lymphocytes isolated from CLL patients and healthy individuals. Flow cytometric assay was used to measure the percentage of apoptosis versus necrosis, intracellular active oxygen radicals (ROS), mitochondrial membrane potential (MMP) and the caspase-3 activity and then mitochondria were isolated from both groups B-lymphocytes...

Comparative assessment of the mitochondrial cytochrome oxidase I (mtCOI) gene sequence uncovers Bemisia tabaci mitotypes. The current study aims to define B. mitotypes found in various agro ecological zones across India. Phylogenetic analysis 13 samples from agroclimatic regions revealed presence four mitotypes: Asia 1, II 5 and 7. Among, 1 was be abundant widespread distribution thirteen locat...

Hypoxic pulmonary vasoconstriction (HPV) is an essential mechanism to optimise lung gas exchange. We aimed to decipher the proposed oxygen sensing mechanism of mitochondria in HPV. Cytochrome redox state was assessed by remission spectrophotometry in intact lungs and isolated pulmonary artery smooth muscle cells (PASMC). Mitochondrial respiration was quantified by high-resolution respirometry. ...

The Lesser Whitethroat Sylvia curruca complex has a wide distribution in the east and west Palaearctic comprises phenotypically very similar, but genetically distinct forms. In order to determine origin of birds wintering on Qeshm Island Persian Gulf, we studied nucleotide sequences mitochondrial cytochrome b gene 23 individuals compared them with publicly available Gen-Bank. from were attribut...

A 19-year-old man born with thyroprivic hypothyroidism, due to congenital development defect, manifested hypogonadism, stunted growth, chronic progressive external ophthalmoplegia (CPEO), diffuse muscle weakness and wasting, right bundle branch block, cerebral atrophy. Muscle biopsy showed mitochondrial abnormalities. Biochemical investigations on muscle disclosed partial (50%) cytochrome c oxi...

Atovaquone is a new anti-malarial agent that specifically targets the cytochrome bc1 complex and inhibits parasite respiration. A growing number of failures of this drug in the treatment of malaria have been genetically linked to point mutations in the mitochondrial cytochrome b gene. To better understand the molecular basis of atovaquone resistance in malaria, we introduced five of these mutat...

Based on the atomic structures of the mitochondrial cytochrome bc(1) complex, it has been proposed that the soluble domain of the [2Fe-2S] Rieske iron-sulfur protein (ISP) must rotate by ca. 60 degrees and translate through an appreciable distance between two binding sites, proximal to cytochrome c(1) and to the lumen-side quinol binding site. Such motional freedom implies that the electron-tra...

Serine/threonine protein kinase B (PKB/Akt) is involved in cell survival and growth. Carboxyl-terminal modulator protein (CTMP), a novel Akt binding partner, prevents Akt activation at the plasma membrane in response to various stimuli, and thus possesses a tumor suppressor-like function. In a previous study, we have demonstrated that CTMP inhibit...

Nitric oxide (NO) is an intercellular signaling molecule; among its many and varied roles are the control of blood flow and blood pressure via activation of the heme enzyme, soluble guanylate cyclase. A growing body of evidence suggests that an additional target for NO is the mitochondrial oxygen-consuming heme/copper enzyme, cytochrome c oxidase. This review describes the molecular mechanism o...

A new species of parasitoid wasp (Braconidae, Microgastrinae) from the kingdom Saudi Arabia (KSA) is described, Microplitis idreesae sp. nov. The genus reported for first time in Eastern province KSA. This host-parasitoid association documented country. attacks Mythimna Ochsenheimer (Lepidoptera, Noctuidae). Natural history information provided such as males with females, geographical location,...