Aim: The aim of the study is to visualize the patency and measure the ostium size at the end of Endonasal DCR with mitomycin C (MMC) versus control and to assess the role of Mitomycin C in maintaining patency of nasolacrimal drainage system. Design: Prospective randomized controlled study Participants: Sixty patients who consented for this study was subjected to endonasal DCR and randomised int...

BACKGROUND Intraabdominal adhesions remain a significant cause of morbidity and mortality. Moreover, intraabdominal adhesions can develop in more than 50% of abdominal operations. AIMS We compared the anti-adhesive effects of two different agents on postoperative adhesion formation in a cecal abrasion model. STUDY DESIGN Experimental animal study. METHODS Forty Wistar albino type female r...

background: using bouginage or balloon dilatation is the standard treatment for benign esophageal strictures. aùžbout two-thirds need repeated dilatations. for preventing recurrent strictures, many medications such as mitomycin-c have been used. mitomycin-c is a special antibiotic with anti-neoplastic characteristics, which inhibits fibroblast proliferation, reduces collagen production and decr...

We examined the effects of mitomycin C and aminopterin on ovulation in vivo and, fertilization, subsequent cleavage and implantation in slc-ICR female mice using methods of fertilization and culture in vitro. Chemicals were injected into mice at the MI (meiosis I) stage or 3 hours before the MI stage in order to examine their toxicity. Mitomycin C did not affect ovulation, but decreased the rat...

Since the original work of Fleming (1), many antibiotics have been isolated from culture filtrates of soil microorganisms. A few of the antibiotics have demonstrated anti-tumor effects in experimental animals (9, 25). Recently, Hata and his associates (8, 12), Sakai and Teranaka (11), and Teranaka (29) reported that mitomycin C, a new antibiotic isolated from Streptomyces caespitosus (4), has s...

Results of a randomized prospective study are reported in which mitomycin C, Tice bacillus Calmette-Guerin (BCG) and RIVM-BCG were compared in 437 patients with primary or recurrent pTa and pT1 bladder tumors, including carcinoma in situ. The followup (or time in study) varied from 2 to 81 months (mean 36 months). After complete transurethral resection of all visible tumors the patients were tr...

Mitomycin-C is an antineoplastic antibiotic that acts as an alkylating agent by inhibiting DNA and protein synthesis. It can inhibit cell division, protein synthesis, and fibroblast proliferation. The purpose of this pilot study is to investigate intraoperative applications of topical mitomycin-C in treatment and prevention of glottic and subglottic stenosis. Eight patients with posterior glott...

OBJECTIVES To clinically evaluate topical mitomycin chemotherapy in patients with diffuse, multifocal, or recurrent primary acquired melanosis with atypia and/or conjunctival malignant melanoma and to histopathologically study ocular tissue samples obtained before and after treatment. METHODS Chemotherapy with topical mitomycin, 0.04% 4 times daily, was administered for 28 days as the primary...

purpose: to determine the efficacy and safety of subconjuctival injection of mitomycin c versus daunorubicin for treatment of pterygium. methods: this randomized double blind placebo-controlled clinical trial included 54 eyes of 36 patients with pterygium who were referred to al-zahra hospital, zahedan-iran in 2004. eyes were randomly assigned to three groups including mitomycin c, daunorubicin...

In recent years, mitomycin C (Fig. 1) has been widely used for cancer treatment, but its clinical applications are limited owing to inherent severe toxicity. The therapeutic efficacy of mitomycin C is closely related to the drug concentration in blood and tissues, depending on the dose, route and frequency of administration. Quantitation of mitomycin C in biological fluids was first attained by...