BACKGROUND Modified Lingguizhugan Decoction (MLD) came from famous Chinese medicine Linggui Zhugan Decoction. The MLD is used for the treatment of metabolic syndrome in the clinical setting. Our study focuses on the comprehensive treatment of MLD incorporated with dietary restriction and exercise in a rat model of the metabolic syndrome (MS). METHODS Rats were divided into five groups: contro...

To the Editor: Metachromatic leukodystrophy (MLD) is a rare lysosomal storage disorder that is caused by a deficiency of the enzyme arylsulfatase A (ARSA). Toxic accumulation of sulfatides in myelin-producing cells of the central nervous system and peripheral nervous system (PNS) results in progressive demyelination. 1 The 3 major forms of MLD are late infantile–, juvenile-, and adult-onset MLD...

[Purpose] The purpose of this preliminary study was to investigate the effect of manual lymph drainage (MLD) of the neck on frontal electroencephalogram (EEG) asymmetry in subjects with psychological stress. [Subjects] Thirteen subjects with psychological stress participated in the study. [Methods] Subjects received MLD of the neck for 15 min. [Results] Analysis of the frontal asymmetry index s...

A Multi Layered Display TM (MLD) uses depth to alter the salience of information. This study considered how the use of depth might influence cursor positioning. As pointing movements to targets may be influenced by flanking nontargets, a MLD was used in an attempt to reduce any distracting effects of non-targets. Participants were 14 skilled computer users who moved a computer cursor using a mo...

The efficacy of doxycycline and ciprofloxacin against an experimental plague infection was assessed by comparing the median lethal dose (MLD) of Yersinia pestis in antibiotic-treated and untreated mice. The MLD of Y. pestis GB strain in untreated mice by the intra-peritoneal route was 23 cfu. If ciprofloxacin dosage (20 or 40 mg/kg twice daily) was initiated 48 h before infection, it afforded c...

Metachromatic leukodystrophy (MLD) is an autosomal recessive lysosomal storage disorder mainly caused by the arysulfatase A (ARSA) gene mutations, which results in ARSA activity deficient to accumulate sulfatide in the oligodendrocytes and in the Schwann cells. On the basis of the age of onset, MLD is characterized by three clinical subtypes: late infantile, juvenile, and adult. In this manuscr...

Competency with numbers is essential in today's society; yet, up to 20% of children exhibit moderate to severe mathematical learning disabilities (MLD). Behavioural intervention can be effective, but the neurobiological mechanisms underlying successful intervention are unknown. Here we demonstrate that eight weeks of 1:1 cognitive tutoring not only remediates poor performance in children with M...

BACKGROUND Different surgical techniques for lumbar discectomy are in vogue. This study compares the outcomes of two techniques for lumbar discectomy, viz. micro lumbar discectomy (LD) and conventional fenestration discectomy. MATERIALS AND METHODS Sixty-six patients who had single-level 'virgin' lumbar disc herniation with unilateral radicular symptoms were included. Of these, 39 had undergo...