Human intestinal absorption (HIA) is an important roadblock in the formulation of new drug substances. In silico models for predicting the percentage of HIA based on calculated molecular descriptors are highly needed for the rapid estimation of this property. Here, we have studied the performance of a support vector machine (SVM) to classify compounds with high or low fractional absorption (%FA...

Two decades ago D. J. Keegan reported results on Egyptian fruit bats (Rousettus aegyptiacus, Megachiroptera) that were strangely at odds with the prevailing understanding of how glucose is absorbed in the mammalian intestine. Keegan's in vitro tests for glucose transport against a concentration gradient and with phloridzin inhibition in fruit bat intestine were all negative, although he used se...

We have developed a technique which allows optical absorption measurements to be made using a pulsed light source and offers a sensitivity significantly greater than that attained using stabilized continuous light sources. The technique is based upon the measurement of the rate of absorption rather than the magnitude of absorption of a light pulse confined within a closed optical cavity. The de...

The delivery of therapeutic proteins has gained momentum with development of biotechnology. However, large molecular weight, hydrophilic nature and susceptibility to harsh environment of gastrointestinal tract (GIT) resulted in low absorption. The main objective of this work was the design of a particulate system for oral delivery of recombinant human growth hormone (rhGH) on the basis of parti...

In the room temperature and nitrogen conditions, we presented well-resolved absorption spectra and indexes of refraction of bactericide molecules in the far infrared radiation (FIR) spectral region recorded by terahertz time-domain spectroscopy (THz-TDS). As illustrative examples we discussed the absorption spectra of captan and folpet in THz region. The absorption coefficient and index of refr...

This paper describes the status of the 2012 edition of the HITRAN molecular spectroscopic compilation. The new edition replaces the previous HITRAN edition of 2008 and its updates during the intervening years. The HITRAN molecular absorption compilation is comprised of six major components structured into folders that are freely accessible on the internet. These folders consist of the tradition...

ABSTRACT Absorption-selected galaxies offer an effective way to study low-mass at high redshift. However, the physical properties of underlying galaxy population remain uncertain. In particular, multiphase circumgalactic medium is thought hold key information on gas flows into and out that are vital for evolution models. Here, we present ALMA observations CO molecular in host H2-bearing absorbe...

We report a λ > ∼ 1 cm search for rotational molecular absorption towards quasars, now possible with the upgraded Australia Telescope Compact Array (ATCA). The targets were PKS 0201+113, PKS 0336–017 and Q 0537–286, where known damped Lyman-alpha absorption systems (DLAs) could cause redshifted molecular absorption in the 12 mm band of the telescope. We place 3σ upper limits on any HCO 0 → 1 ab...

Our observations with the ISO SWS revealed that H2O band at 2.7μm appears as absorption already in an M2 giant β Peg and strengthens towards later M giants. Further, CO2 4.2μm band appears as absorption in an M7 giant SWVir and especially strong in a Mira variable SVir. The excitation temperatures of these molecular bands estimated from their band shapes turn out to be 750 – 1,250K in M giants ...

We describe an integrated, molecular-absorbance, atomic absorption instrument for studying metal/ligand binding in clinical samples. For an interface between the "high-performance" liquid chromatograph and the atomic absorption instrument we used a flow-injection sample manipulator, thus allowing both the chromatograph and the atomic absorption detector to operate at their separate optimum cond...