Congenital cytomegalovirus (cCMV) infection is a leading non-genetic cause of sensorineural hearing. Alethia CMV assay proved to be accurate, simple and appears suitable for testing using neonatal saliva. However, long storage swab samples not validated across different time periods temperature. This study verifies the effects temperature in detection from saliva molecular developed by Alethia.

Objective(s): Juglone is isolated from many species of the Juglandaceae family and used as an anti-viral, anti-bacterial, and anti-tumor therapeutic. Here, we evaluated juglone-induced antitumor effect in ovarian cancer SKOV3 cells. Materials and Methods: MTT assay was performed to examine juglone anti-proliferative effect. Cell cycle and apoptosis were studied using flow cytometry in juglone-t...

For many years, the risk-based therapy stratification of children with neuroblastoma has relied on clinical and molecular covariates. In recent genome analysis revealed further alterations defining risk, tumor biology, therapeutic targets. The implementation a robust scalable method for analyzing traditional new markers in routine diagnostics is an urgent need. Here, we investigated targeted pa...

  Background: Due to some limitations of serological methods in diagnosis of patients infected with HIV-1 (human immunodeficiency virus) and HCV (hepatitis C virus), it is profoundly important to use molecular methods for the detecting of these infectious agents. However, the most significant problems are the exorbitant cost of these methods and the need of a thermocycler which is an expensive...

objective(s): first, 10-bromodecanoic acid was covalently attached to all available surface primary amines of ppi g2 and g3 to increase their lipophilicity. in the subsequent step, ppis were conjugated to the alkylcarboxylate groups of alkylcarboxylate-ppi derivatives to increase the number of surface primary amines. physicochemical properties of modified ppis were determined. transfection expe...

purpose: the aim of this study was to test the in vitro sensitivity of lymphocytes of patients with head and neck cancer against gamma irradiation and also to find out if the frequencies of chromosomal aberrations correlate with side effects of radiotherapy. patients and methods : peripheral blood of 101 patients with head and neck cancer was collected before the onset of radiotherapy, cultured...

Molecular mobility is important for interactions of biofunctional polymers with target molecules. Monomer structures synthetic are usually selected based on their compatibility polymerization systems, whereas the influence monomer interaction molecules hardly considered. In this report, we evaluate correlation between glycopolymers and concanavalin A (ConA) respect to molecular mobility. Two ty...

Interspecies interaction of actinomycetes will express new gene clusters and may therefore affect the pigmentation, sporulation and production of secondary metabolites. Actinomycetes strains were isolated from Howze Soltan Salt Lake. Binary actinomycete interaction assay was conducted to evaluate its effect on colony morphology and antibiotic production. The molecular identification of the indu...