Background: Hsp110, an Hsp70 homolog, is highly efficient in preventing protein aggregation, but lacks the folding activity seen in Hsp70s. Result: In contrast to Hsp70s, Hsp110s exhibit distinct peptide substrate binding properties. Conclusion: The peptide substrate binding properties determine the chaperone activity differences between Hsp70s and Hsp110s. Significance: Our studies shed light ...
