نتایج جستجو برای: molecular diagnostics
تعداد نتایج: 664640 فیلتر نتایج به سال:
Gold nanoparticles (AuNPs) exhibit a unique phenomenon, known as surface plasmon resonance, which is responsible for their large absorption and scattering cross-sections, which are four to five orders of magnitude larger than those of conventional dyes. In addition, their optical properties can be controlled by varying their sizes, shapes and compositions. AuNPs can be easily synthesized and fu...
DNA-based methods have been available for many years in most clinical microbiology laboratories. However, until recently, these tools were not routinely exploited for the diagnosis of parasitic infections. Laboratories were reluctant to implement PCR, not knowing how to incorporate such an approach in the algorithm of tools available for the most accurate diagnosis of a large variety of parasit...
The histiocytoses are a group of rare proliferative disorders derived from dendritic cells and macrophages. The prognosis is variable, ranging from benign lesions though chronic debilitating illness to rare true malignant disorders. Diagnosis is by clinical features, histology including morphology and immunohistochemistry, and recently in haemophagocytic lymphohistiocytosis, using molecular dia...
In the daily routine of a clinical microbiological laboratory, pathogens can be detected in several ways. Diagnostics of infectious diseases require a strategic approach, since the etiological agent can be of bacterial, viral, fungal or protozoan origin, frequently sharing an identical syndrome. A complicating factor is that the clinical sample, sent to the laboratory, can be severely contamina...
PURPOSE OF REVIEW The purpose of this article is to review the molecular methods commonly used in medical microbiology as well as to update the clinician as to newer molecular technologies that show promise in the identification of microorganisms as well as evaluation of the presence of virulence factors and antibiotic resistance determinants. RECENT FINDINGS Numerous molecular assays have be...
Since the discovery of the JAK2 V617F mutation in the majority of the myeloproliferative neoplasms (MPN) of polycythemia vera, essential thrombocythemia and primary myelofibrosis ten years ago, further MPN-specific mutational events, notably in JAK2 exon 12, MPL exon 10 and CALR exon 9 have been identified. These discoveries have been rapidly incorporated into evolving molecular diagnostic algo...
Clinical tests based on primer-initiated amplification of specific nucleic acid sequences achieve high levels of sensitivity and specificity. Despite these desirable characteristics, these tests have not reached their full potential because their complexity and expense limit their usefulness to centralized laboratories. This paper describes a device that integrates sample preparation and loop-m...
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