Steric effects of various polar and some charged groups were estimated on sterically crowded cyclopropane cis-1,2-bis derivatives 2 or 3, in which the variable substituent is in the proximity of a t-butyl group or of a methyl group. The steric energy was evaluated with reference to the pertinent mono derivatives, that is as reaction energy of an isodesmic reaction, in which the crowded compound...

abstractpyrimidine nucleosides are constituents of fundamental structure of the cells. there has been considerable attentions in the chemistry of pyrimidine derivatives due to having a wide range of biological activities such as antiviral, anti-malarial agents, cytostatic, antithelemintic, antibacterial, adenosine receptor ligands, anti-cancer agents, compounds targeting delayed-type hypersensi...

A new rapid iodination reagent, N1,N3,N5-tris[(2,4,6-trimethylpyridine)iodo(I)]-2,4,6-triphenyl-s-triazine trihexafluorophosphate, was synthesized in a modification of the established synthesis 2,4,6-triiodo-3,5-dimethylphenol presence bis(2,4,6-trimethylpyridine)iodo(I) hexafluorophosphate and used for precise post-modification mono- trisubstituted phenyl compounds. We performed triple iodinat...

Mono and bis hexamethylenetetramine iron(III) chloride, Fe(N C ,H ) CI (I) and Fe(N C ,H ) Cl (II) were synthesized by the reaction of iron(III) chloride and hexamethylenetetramine (HMTA) in chloroform. Chemical analysis and spectral results show the coordination of HMTA to the iron(III). Electronic transition spectra of compound I and I1 were also studied in coordinating and noncoordinatin...

Identification of novel brominated contaminants in the environment, especially the derivatives and byproducts of brominated flame retardants (BFRs), has become a wide concern because of their adverse effects on human health. Herein, we qualitatively and quantitatively identified three byproducts of tetrabromobisphenol-S bis(2,3-dibromopropyl ether) (TBBPS-BDBPE), including TBBPS mono(allyl ethe...

In this paper we report the synthesis of three families of new amidine–based aromatic derivatives as potential DNA minor groove binding agents for the treatment of cancer. The preparation of mono–guanidine, mono–2–aminoimidazoline and asymmetric diphenyl guanidine/2–aminoimidazoline derivatives (compounds 1a,b,c to 8a,b,c) is presented. The affinity of these substrates and of a family of mono– ...

mono and bis hexamethylenetetramine iron(iii) chloride, fe(n c ,h ) ci (i) and fe(n c ,h ) cl (ii) were synthesized by the reaction of iron(iii) chloride and hexamethylenetetramine (hmta) in chloroform. chemical analysis and spectral results show the coordination of hmta to the iron(iii). electronic transition spectra of compound i and i1 were also studied in coordinating and noncoordinating so...

Aim: To study the effect of new synthesized pyrimidine derivatives on growth Mycobacterium lufu ( M. ) and tuberculosis when cultivated Shkolnikova’s medium. Materials methods. The objects research were 6 samples - 5-(arylmethylidene)-2,4,6-pyrimidine-2,4,6(1 H ,3 ,5 )-trions under laboratory codes TAG1, TAG2, TAG3, TAG4, TAG5, TAG6 7 5-(getarylmethylidene)-2,4,6-pyrimidine-2,4,6(1 , 3 5 TAG7, ...