methotrexate is an anti-rheumatic agent used as a first-line tretment for rheumatoid arthritis. hematological malignancies like lymphoma or acute myeloid leukemia have been reported to be secondary to treatment with methotrexate, but are very uncommon. we report here the first moroccan case of ra patient on low dose mtx, who developed aml. we also reviewed all similar cases.

INTRODUCTION Popliteal pterygium syndrome is a congenital malformation that includes orofacial, musculoskeletal and genitourinary anomalies. It is a rare autosomal dominant disorder due to a mutation of the IRF6 gene on 1q32.2. CASE PRESENTATION A one-month-old Moroccan baby boy was diagnosed with typical features of popliteal pterygium syndrome and carried the c.250C>T; p.Arg84Cys mutation o...

We report the case of a Moroccan boy with mental retardation, hyperactivity, epilepsy, developmental problems and behavioural disorders. Cytogenetic analysis showed the presence of a supernumerary marker chromosome. Molecular cytogenetics allowed us to determine the marker as an inverted duplication of chromosome 15. It is the first case of a Moroccan patient with tetrasomy 15q in which fluores...

This paper reports the recent progress on mud volcanism data accumulation in the case of the Gulf of Cadiz area. The discovery of giant mud volcanoes, deep coral reefs, and gas hydrates in 1999, from the Guadalquivir Diapiric Ridge to the Larache Moroccan margin, launched a dynamic expansion of new projects (GeNesis, MoundForce, HERMES) and international oceanographic campaigns (R/V Sonne, Mari...

In their travel writings about Europe in the 19th century, Moroccan visitors compare and contrast what they see of the European artistic designs and aesthetic values with experiences from their own native cultures. In this paper, I analyze the discourse and rhetoric about the enjoyment of nature, landscape design and leisure aesthetics as explored in the travel writing of the Moroccan traveler ...

This paper examines intrinsic vowel pitch (IF0) in Moroccan Standard Arabic and Belgian Standard Dutch in order to investigate the hypothesis that IF0 may depend on the size of the vowel inventory. The results of a production task with 11 Moroccan native speakers of Standard Arabic and 10 Belgian native speakers of Dutch reveal that IF0 in Arabic is significantly smaller (1.28 ST) than in Dutch...

The short tandem repeat (STR) systems D3S1358, TH01, D21S11, D18S51, Penta E, D5S818, D13S317, D7S820, D16S539, CSF1PO, Penta D, vWA, D8S1179, TPOX and FGA were studied in Arabian population samples from Morocco and Syria. No significant deviation from Hardy-Weinberg equilibrium could be observed in either preparation. Comparing the Moroccan and Syrian populations using the program RxC, no simi...