OBJECTIVES Cytomegalovirus infections cause the most frequent infection after solid-organ transplant. While Cytomegalovirus prophylaxis is established in high-risk patients (donor+/ recipient-), data on Cytomegalovirus prophylaxis in other serostatus constellation are rare. The aim of this study was to evaluate the influence of Cytomegalovirus treatment strategy after a liver transplant (preemp...

The human cytomegalovirus (HCMV) glycoprotein US11 diverts class I major histocompatibility complex (MHC) heavy chains (HC) from the endoplasmic reticulum (ER) to the cytosol, where HC are subjected to proteasome-mediated degradation. In mouse embryonic fibroblasts that are deficient for X-box binding protein 1 (XBP-1), a key transcription factor in the unfolded protein response (UPR) pathway, ...

background : cytomegalovirus (cmv) is the most common cause of congenital infection, with increased morbidity and mortality at birth. the risk of intrauterine infection largely depends on the time of maternal infection during pregnancy. currently, no national screening test for cmv infection is available during pregnancy in iran. the aim of this study was to determine the seroprevalence of cmv ...

Autoimmune and autoinflammatory diseases are rare but often devastating disorders, underpinned by abnormal immune function. While some autoimmune disorders thought to be triggered a burden of infection throughout life, others genetic in origin. Among these heritable the type I interferonopathies, including Mendelian childhood-onset encephalitis Aicardi-Goutières syndrome. Patients with Aicardi ...

With the appearance of worldwide AIDS pandemic four decades ago came a number debilitating opportunistic infections in patients immunosuppressed by pathogenic human retrovirus HIV. Among these was severe sight-threatening retinal disease caused cytomegalovirus (HCMV) that remains today significant cause vision loss and blindness untreated without access or sufficient response to combination ant...

The human cytomegalovirus (HCMV) major immediate-early enhancer has been postulated to play a pivotal role in the control of latency and reactivation. However, the absence of an animal model has obstructed a direct test of this hypothesis. Here we report on the establishment of an in vivo, experimentally tractable system for quantitatively investigating physiological functions of the HCMV enhan...