Tyrosine kinase inhibitors (EGFR-TKIs) targeting the epidermal growth factor receptor (EGFR) have been used in non-small cell lung carcinoma (NSCLC) for years with promising results, in particular in patients with activating mutations in the EGFR kinase domain (exon 19 E746-A750 deletion or exon 21 L858R point mutation). However, despite their great success in the clinic, a significant number o...

Colorectal cancer (CRC) is prevalent worldwide, and treatment often involves surgery and genotoxic chemotherapy. DNA repair mechanisms, such as base excision repair (BER) and mismatch repair (MMR), may not only influence tumour characteristics and prognosis but also dictate chemotherapy response. Defective MMR contributes to chemoresistance in colorectal cancer. Moreover, BER affects cellular s...

Primary astrocyte cultures were used to investigate the modulation of DNA repair as a tool for sensitizing astrocytes to genotoxic agents. Base excision repair (BER) is the principal mechanism by which mammalian cells repair alkylation damage to DNA and involves the processing of relatively nontoxic DNA adducts through a series of cytotoxic intermediates during the course of restoring normal DN...

OBJECTIVES This study sought to investigate the clinical utility of aortic valve calcium score (AVCS) determined by using cardiac multislice computed tomography (MSCT). METHODS Data of 1315 consecutive patients who underwent both conventional echocardiography and MSCT were reviewed. Degree of aortic stenosis (AS) was assessed according to mean pressure gradient (mPG) measured by echocardiogra...

OBJECTIVE To examine the pressure gradient and peripheral fractional flow reserve (pFFR) measured by a pressure wire as indicators of hemodynamic significance in iliofemoral angiographic intermediate stenosis. BACKGROUND The utility of pressure measurements using a pressure wire with vasodilators is unclear in cases with intermediate iliofemoral stenosis. METHODS The mean pressure gradient ...

Storage of botanical extracts reduced the effectiveness on radial growth Fusarium oxysporum but enhances in case Modified Panchagavya (MPG). The mean F. at 0, 2, 4, 6, 8 and 10 days storage were 38.83, 42.68, 46.61, 51.07, 56.04 60.73 per cent respectively. Garlic extract showed no 0 day 10.00 mm was observed two period which increased with an increase time highest 52.50 69.84 inhibition period...

The role of gamma-aminobutyric acid-A (GABAA) and GABAC receptors in the GABA-induced biphasic response in neurons of the rat major pelvic ganglia (MPG) were examined in vitro. Application of GABA (100 microM) to MPG neurons produced a biphasic response, an initial depolarization (GABAd) followed by a hyperpolarization (GABAh). The input resistance of the MPG neurons was decreased during the GA...

The major obstacle to clinical development of siRNAs (short interfering RNAs), like for most of the nucleic-acid-based strategies, is their poor cellular uptake and bioavailability. Although several viral and non-viral strategies have been proposed to improve siRNA delivery, their applications in vivo remain a major challenge. We have developed a new strategy, based on a short amphipathic pepti...

Introducción: la predisposición hereditaria causada por mutaciones patogénicas de línea germinal (MPG) explica hasta el 10% los cánceres mama. Para reducir su impacto en mujeres mutadas se han propuesto diferentes estrategias, tales como las cirugías reductoras riesgo o screening con resonancia magnética (RM) mamas.Métodos: este estudio observacional retrospectivo analizaron registros portadora...

Microgrids are an effective solution to decentralize electrical grids and improve usage of distributed energy resources (DERs). Within a microgrid there multiple active players it can be computationally expensive consider all their interactions. An optimal scheduler ensures that the needs within met without wasting electricity. With higher requirements for electric vehicle charging stations (EV...