The aim of the study was to investigate dynamic changes in α-melanocyte-stimulating hormone (α-MSH) levels in the serum of patients with craniocerebral trauma. Forty-eight patients with acute craniocerebral injury were selected between January 2015 and October 2016. The patients were divided into three groups: severe (18 cases), moderate (16 cases) and mild (14 cases), according to the Glasgow ...

Melanocyte-stimulating hormone (alpha-MSH) increases cytosolic levels of cAMP as well as tyrosinase activity in murine melanocytes. These activities depend upon the presence of melanin precursors and may differ in human melanocytes. In this study, we demonstrate that high levels of tyrosine (3.7 mM), the chief melanin precursor, reduced the proliferative effect of alpha-MSH and altered human me...

The proteolytic processing pattern of pro-ACTH/endorphin in rat hypothalamus is similar to the pattern in the pars intermedia; peptides the size of beta-endorphin, gamma-lipotropin (gamma-LPH), corticotropin-like intermediate lobe peptide (CLIP), alpha-melanotropin (gamma-MSH), joining peptide, and glycosylated gamma 3-MSH all represent predominant end products. Equimolar amounts of beta-endorp...

γ-Melanocyte-stimulating hormone (γ-MSH), atrial natriuretic peptide (ANP), and oxytocin have been identified as candidate hormonal mediators of the reflex natriuresis that follows acute unilateral nephrectomy (AUN). Pharmacological characterization of the third melanocortin receptor (MC3-R) indicates that it uniquely responds to physiological concentrations of γ-MSH. We tested the roles of γ-M...

Amaç: Futbolcuların maksimum sprint hızı (MSH), aerobik hız (MAH), anaerobik rezervi (AHR) ve VO2max sonuçları ile tekrarlı performansları arasındaki ilişkiyi incelemektir. Gereç Yöntemler: Çalışmaya 73 gönüllü erkek futbolcu katılmıştır. Araştırma 48 saat aralıkla 2 oturumdan oluşmuştur. İlk oturumda 10 m sürat testi 6x35 uygulanmıştır. İkinci ise Yo Yo-1 test MSH, MAH, AHR hesaplanmıştır. Par...

background:chronic active adrenocorticotropin hormone (acth) immunization of ewes (with a previous history of immunization) resulted in elevated titres of antibody against acth, which induced a reduction in circulating levels of cortisol. objectives:the aim of the present study was to investigate: a) the influence of active immunization against acth on milk production of the ewe as assessed by ...

Many homeobox-containing genes of Drosophila regulate pathways of differentiation. These proteins probably function as promoter- or enhancer-selective transcription factors. We have isolated a new homeobox-containing gene, msh-2, by means of the polymerase chain reactions (PCR) using redundant primers. msh-2 is specifically expressed in mesodermal primordia during a short time period early in d...

Systemically administered α-melanocyte-stimulating hormone (α-MSH) inhibits endotoxin (lipopolysaccharide; LPS)- or interleukin (IL)-1-induced fever and adrenocortical activation, but the sites of these actions and the mechanisms involved are unknown. The aims of this study were, first, to determine whether melanocortin receptors (MCR) located within the central nervous system mediate the suppr...

Caenorhabditis elegans expresses five family members of the translation initiation factor eIF4E whose individual physiological roles are only partially understood. We report a specific role for IFE-2 in a conserved temperature-sensitive meiotic process. ife-2 deletion mutants have severe temperature-sensitive chromosome-segregation defects. Mutant germ cells contain the normal six bivalents at ...

INTRODUCTION AND PURPOSE Diffusion weighted imaging (DWI) has been proven to be valuable in the diagnosis of middle ear cholesteatoma. The aims of our study were to evaluate the advantage of multi-shot turbo spin echo (MSh TSE) DWI compared to single-shot echo-planar (SSh EPI) DWI for the diagnosis of cholesteatoma. MATERIAL AND METHODS Thirty-two patients with clinical suspicion of unilatera...