Diversity-generating retroelements (DGRs) recognize novel ligands through massive protein sequence variation, a property shared uniquely with the adaptive immune response. Little is known about how recognition is achieved by DGR variable proteins. Here, we present the structure of the Bordetella bacteriophage DGR variable protein major tropism determinant (Mtd) bound to the receptor pertactin, ...

Muscle tension dysphonia (MTD) is a voice disorder that occurs as a result of misuse or abuse of the voice [1]. While there is no neurological damage to the larynx nor any structural abnormality present, patients with MTD have limitations in vocal vibrations due to laryngeal muscle tension. Consequently, such patients demonstrate pathological voice problems, such as hoarseness, strained and str...

Question 18. Is it possible to achieve in practice those actual MTD advantages with respect to other methods on efficiency and throughput at some decimal powers (100-1000 times!), which ones formally follow from estimations for a hardware decoder project? Yes, it is. The unconditional regularity of our approach to estimations of hardware decoding efficiency is doubtless. It consists simply that...

Linear Go is the game of Go played on the 1×n board. Positional Linear Go is Linear Go with a rule set that uses positional superko. We explore gametheoretic properties of Positional Linear Go, and incorporate them into a solver based on MTD( f ) search, solving states on boards up to 1×9.

With the increased frequency and intensity of denial-of-service (DoS) attacks on critical cloud-hosted services, resource adaptation schemes adopted by cloud service providers (CSPs) need to be intelligent. Specifically, they adaptable attack behavior dynamic curb over-utilization. The concept moving target defense (MTD) has recently emerged as an effective agile mechanism against DoS that part...

Introduction In recent years, more evidence is emerging in favor of a new form depression, aka “Modern-Type Depression” (MTD). It has also been theorized that MTD may have multiple relationships with other psychiatric disorders, including techno-addictions. Objectives Our study aims at clinically characterizing subjects sample individuals affected Internet Gaming Disorder (IGD). Methods 1,157 w...

The Mixture Transition Distribution model (MTD) was introduced by Raftery (1985) for the modeling of high-order Markov chains with a nite state space. Since then, it has been generalized and successfully applied to a range of situations including the analysis of wind direction, DNA and social behavior. Here we review the MTD model and the developments since 1985. We rst introduce the basic prin...

The mixture transition distribution model (MTD) was introduced in 1985 by Raftery for the modeling of high-order Markov chains with a finite state space. Since then it has been generalized and successfully applied to a range of situations, including the analysis of wind directions, DNA sequences and social behavior. Here we review the MTD model and the developments since 1985. We first introduc...

We propose a method for estimating axonal fiber connectivity pathways (cerebral connectivity fibers) from Multi-Tensor Diffusion Magnetic Resonance Imaging (MTD-MRI). Our method uses multiple local orientation information provided by MTD-MRI for leading stochastic walks of particles. We perform stochastic walks on particles with mass which introduce inertia and gravitational forces that result ...

A rapidly increasing number of Phase I dose-finding studies, and in particular those based on the standard 3+3 design, are being prolonged with the inclusion of dose expansion cohorts (DEC) in order to better characterize the toxicity profiles of experimental agents and to study disease-specific cohorts. These trials consist of two phases: the usual dose escalation phase that aims to establish ...