نتایج جستجو برای: multi drug resistant bacteria
تعداد نتایج: 1331998 فیلتر نتایج به سال:
Some varieties of human cancers become resistant, or, are intrinsically resistant to treatment with conventional drug therapies. This phenomenon is due largely to over-expression of the ATP binding cassette, (ABC), super-family of membrane transporters. In this regard, 170 kDa plasma membrane ATP-dependent pump, known as P-glycoprotein are the most important. Other members of multi-drug resista...
The rapid spread of multi-drug resistant pathogens represents a serious threat to public health, considering factors such as high mortality rates, treatment restrictions and high prevalence of multi-drug resistant bacteria in the hospital environment. Antimicrobial peptides (AMPs) may exhibit powerful antimicrobial activity against different and diverse microorganisms, also presenting the advan...
Infectious diseases caused by bacterial pathogens represent a serious public health concern. Antimicrobial agents such as anti-bacterial drugs are often indicated for chemotherapy of bacterial infections in clinical medicine. Thus, it is important to study the biological mechanisms that confer bacterial pathogenesis and virulence. Under selective evolutionary pressure when in the presence of an...
Emergence of multi and pan-drug resistant Gram-negative bacteria causing nosocomial infections in intensive care settings has become a challenge for clinicians. The mortality rate of ventilator-associated pneumonia (VAP) is known to increase when the initial microbiological diagnosis and antimicrobial therapy are inappropriate. We present a case of a 18-year-old man, who after being admitted fo...
The treatment of meningitis is a complex issue when it comes to multi-resistant antibiotic (ATB) bacteria, limiting the drug options that can cross blood-brain barrier and effectively reach subarachnoid space. impact on effectiveness therapeutic arsenal available, due indiscriminate use antibacterial global scale, increases chances failure initial empirical persistence despite culture targeting...
Polymyxins were discovered in the 1940s and used to treat infections caused by gram-negative bacteria. These molecules act destroying cell membrane through destabilization of phospholipids lipopolysaccharides (LPS). Due adverse effects, such as nephrotoxicity neurotoxicity, this class had seen limited use. However, with evolution antimicrobial resistance commercial drugs, use polymyxins has res...
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