Multidrug resistance (MDR) of human cancers is the major cause of failure of chemotherapy. To better understand the molecular events associated with the development of different types of MDR, two different multidrug-resistant gastric carcinoma cell lines, the MDR1/P-glycoprotein-expressing cell line EPG85-257RDB and the MDR1/P-glycoprotein-negative cell variant EPG85-257RNOV, as well as the cor...

BACKGROUND The relationship between multidrug resistance (MDR), inappropriate empiric therapy (IET), and mortality among patients with Acinetobacter baumannii (AB) remains unclear. We examined it using a large U.S. METHODS We conducted a retrospective cohort study using the Premier Research database (2009-2013) of 175 U.S. hospitals. We included all adult patients admitted with pneumonia or s...

Multidrug-resistant tuberculosis (MDR-TB) is an infectious disease caused by Mycobacterium which resistant to at least isoniazid and rifampicin. This a worldwide threat complicates the control of (TB). Long treatment duration, combination several drugs, adverse effects these drugs are factors that play role in poor outcomes MDR-TB patients. There have been many studies with repurposed improve o...

Multidrug resistance (MDR) occurs frequently after long-term chemotherapy, resulting in refractory cancer and tumor recurrence. Therefore, combatting MDR is an important issue. Autophagy, a self-degradative system, universally arises during the treatment of sensitive and MDR cancer. Autophagy can be a double-edged sword for MDR tumors: it participates in the development of MDR and protects canc...

Tumor cells may display a multidrug resistance phenotype by overexpression of ATP binding cassette transporter genes such as multidrug resistance (MDR) 1 P-glycoprotein (P-gp) or the multidrug resistance protein 1 (MRP1). MDR3 P-gp is a close homologue of MDR1 P-gp, but its role in MDR is probably minor and remains to be established. The MRP1 protein belongs to a family of at least six members....

Drug-resistant tuberculosis is a public health concern. TB that drug-resistant to rifampin and isoniazid known as MDR-TB, whereas XDR-TB MDR-TB also resistant second-line medicines, such fluoroquinolones (levofloxacin, ofloxacin, moxifloxacin). rifampin-resistant (RR-TB), of which 78 percent had multidrug-resistant (MDR-TB) (MDR-TB). Fluoroquinolones are class broad-spectrum antimicrobials have...

OBJECTIVE To determine the time from diagnosis to start of multidrug resistant tuberculosis (MDR TB) treatment in Lima, Peru. METHODS We studied new smear-positive TB adults that were started on MDR TB treatment or that were switched to it between June 2008 and December 2011. RESULTS Time from the first positive smear to MDR-TB treatment was >30 days in 35% (13/37) of patients. Among the 27...

Despite progress made in tuberculosis control worldwide, the disease burden and treatment outcome of multidrug-resistant tuberculosis (MDR-TB) patients have remained virtually unchanged. In 2016, the World Health Organization released new guidelines for the management of MDR-TB. The guidelines are intended to improve detection rate and treatment outcome for MDR-TB through novel, rapid molecular...

We characterized a multidrug-resistant (MDR) Enterobacter spp. isolate highlighting the genetic aspects of antimicrobial resistance genes. An (Ec61) was recovered in 2014 from transtracheal aspirate sample patient admitted to Brazilian tertiary hospital and submitted further microbiological genomic characterization.

Multidrug resistance (MDR) proteins serve as transporters for chemical compounds, small molecules like antibiotics in almost all species from bacteria to higher eukaryote. They provide the resistance against antibiotics and chemicals for the cells like cancer, fungi and parasite, etc. Therefore, the research on MDR proteins is essential and important in medical, agricultural and scientific fiel...