In a recent issue of Blood, Saeed et all reported about the prognostic significance of plasma cell acid phosphatase (PCAP) in a large number of patients with multiple myeloma, showing that a low PCAP score (< 130) at diagnosis might recognize a subgroup of myelomatous patients with poor prognosis. I believe that such findings are quite surprising in view of the previously published cumulative d...

Overexpression of growth differentiation factor 15 (GDF15) by bone marrow mesenchymal stem cells occurs widely in patients with multiple myeloma, but the pathophysiologic effects of GDF15 in this setting remain undefined. GDF15 has been described in numerous solid tumors but never in hematologic malignancies. In this study, we report that GDF15 significantly increases survival of stroma-depende...

Multicentric Castleman's disease (MCD) is a rare lymphoproliferative disorder of unknown etiology and characterized by various clinical manifestations and multiple organ involvement. It has been reported in association with POEMS syndrome and can progress to Kaposi's sarcoma or malignant lymphoma. The disease runs a more aggressive course and a poor prognosis. Optimal therapies have not been we...

Morphological characteristics of tumor cells have been employed in the prognosis of lymphomas and solid tumors. This report documents an attempt to predict survival from the known cytologic heterogeneity in multiple myeloma. Myeloma cells in bone marrow smears from patients at diagnosis were evaluated by assigning them to morphologically defined categories. Cox's multivariate regression model f...

Introduction. Kidney failure in multiple myeloma is some-times initial symptomatology and a very serious complication with an unfavorable effect on the course prognosis of disease. Multiple disease characterized by proliferation plasmocytes bone marrow, rare cases, it can be extramedullary various organs systems. Pulmonary plasmacytoma localization localization, especially when represents one m...

•A patient with rare solitary ovarian plasmacytoma is reported•Diagnostic work-up is mandatory to rule out ovarian involvement as part of multiple myeloma.•After complete surgical resection, the prognosis appears to be very favorable.

recent evidences suggest that multiple myeloma phenotypes (mmps) are involved in the infiltration of multiple myeloma-affected marrow foci. in this study, the effects of arsenic trioxide on the invasive and angiogenic phenotypes of multiple myeloma (mm) cell line were assessed on a dose-response and time-course basis. multiple myeloma cell line, karpas 707, was treated with step-wise elevated c...

In a recent issue of Blood, Saeed et all reported about the prognostic significance of plasma cell acid phosphatase (PCAP) in a large number of patients with multiple myeloma, showing that a low PCAP score (< 130) at diagnosis might recognize a subgroup of myelomatous patients with poor prognosis. I believe that such findings are quite surprising in view of the previously published cumulative d...

Background: The risk of injury to the kidney can be significantly exacerbated by presence tumors and effects related treatments. Kidney associated with cancer is common in multiple myeloma, tumor lysis syndrome, hematopoietic stem cell therapy, chemotherapy. Cancer patients are at increased infection, sepsis, drug-related toxicity, other comorbidities, leading a acute (AKI). This study retrospe...