how to cite this article: najafi mr, najafi ma, nasr z. diagnosis and management of multiple sclerosis in children. iran j child neurol. summer 2016; 10(3): 13-23. abstract growing evidence indicates the safety and well toleration of treatment by disease-modifying in children suffering multiple sclerosis (ms). the treatment is not straight forward in a great number of patients, thus patients wi...

patients and methods this cross-sectional study was performed on 1202 ms patients in farshchian hospital, hamadan, in 2013. all patients were diagnosed with definite ms. a questionnaire was used to gather information; demographic characteristics, medical history, signs and symptoms at onset, course of disease, relatives with ms, and degree and type of relationship were recorded. conclusions the...

results the results showed that there was no statistical significant difference in distribution of genotype (aa, ac and cc) and allele (a and c) frequencies between ms patients and healthy controls (p = 0.901 and p = 0.728, respectively). conclusions in conclusion, it appears that the c424c/a polymorphism within the il-25 gene has no significant relationship with ms, and this polymorphism is pr...

optic neuritis occurs in young patients, most often females, and presents as subacute monocular visual loss. periocular pain, particularly with eye movement occurs in the majority of cases. the retrobulbar form occurs in 65% of cases and is associated with normal optic disc appearance at onset. the central visual field is usually affected and an rapd and dyschromatopsia are present. brain magne...

multiple sclerosis (ms) is an inflammatory disease of the central nervous system (cns). inflammation caused by immune cells destroy the myelin and then axon. cns failure to complete repair results in permanent disabilities. some types of stem cells have special potentials to repair these injuries and even cure ms. neural crest stem cells with a mutual origin with cns and the ability of differen...

melatonin has both pro-inflammatory and anti-inflammatory properties depending on the stage of inflammation. despite its therapeutic effect in alleviation of some symptoms of multiple sclerosis; the precise role of melatonin in ms pathogenesis remains a topic of debate. the aim of this study was to measure the urine level of one of melatonin products which is an index of serum melatonin level, ...

objective: multiple sclerosis (ms) is a chronic disease with prominent neurological and behavioral and psychiatric manifestations and unknown etiology which is demarcated with inflammation and destruction of white matter of brain and spinal cord and its replacement with gliotic tissue in young aged people and particularly females. the role of trace elements in multiple sclerosis is set forth in...

multiple sclerosis (ms) is an autoimmune disease that affects physical and emotional aspects of patient's lives. the aim of this study was to evaluate emotional intelligence (ei) in cases with ms.one hundred sixty six clinically definite ms and 110 healthy subjects were enrolled in this study. all participants filled valid and reliable persian version emotional quotient inventory (eq-i) questio...