OBJECTIVES The aim of this study was to estimate the frequency of triple- and quadruple-resistant Helicobacter pylori isolated in Germany, to characterize those isolates molecular genetically and to identify risk factors for the development of multiresistance. METHODS Antimicrobial susceptibility to metronidazole, clarithromycin, amoxicillin, tetracycline, ciprofloxacin/levofloxacin and rifam...

1 integron showed 100% nucleotide sequence identity to the corresponding segment of a plasmid from the human clinical P. aeruginosa strain B3 isolated in Guangzhou (accession no. EU588392). Moreover, the 3 ′ conserved region of the integron (qacED1 and sul1) and the upstream region of the bla IMP-45 gene including aacA4, the 5 ′ conserved segment (intI1) of the integron and a Tn1403-like transp...

Forty-eight Streptococcus pneumoniae isolates recovered from sputum samples from 26 cystic fibrosis (CF) patients attending our CF unit (1995 to 2003) were studied. Mean yearly incidence of isolation was 5.5%, and all were strains recovered from young patients (< or = 12 years). The isolation was linked to clinical exacerbation in 35% of the cases, but only 27% of these were not accompanied by ...

In most gram-negative bacteria, acquired multiresistance is conferred by large plasmids compiling numerous antimicrobial resistance genes. Here, we show an evolutionary alternative strategy used by Pasteurella multocida to become resistant to multiple clinically relevant antibiotics. Thirteen beta-lactam-resistant clinical isolates, concomitantly resistant to tetracyclines and/or streptomycin a...

Background: Staphylococcus hominis has been recently emerged as an opportunistic hospital-associated pathogen. The aim of this study was to characterize the antimicrobial susceptibility pattern, biofilm formation, and staphylococcal cassette chromosome mec (SCCmec) types among clinical isolates of S. hominis obtained from pediatric infections. Methods: Totall...