Papillomaviruses are a group of DNA viruses belonging to the Papillomavirida family. These provoke pathological conditions manifesting with inflammation, exophytic masses, carcinogenesis, reproductive and perinatal disorders. Immune status is an essential factor de-termining severity duration inflammatory diseases, course latent viral infections, including papillomavirus infection (PVI). The hu...

Amyotrophic lateral sclerosis (ALS) is a progressive degenerative disease of motor neurones. There is a family history in approximately 10% percent of cases. Only 20% of such families have point mutations in the Cu, Zn superoxide dimutase 1 (SOD1) gene. Pre-symptomatic loss of motor neurons has been identified prior to the onset of symptoms in SOD1 mice. This loss was biphasic with initial loss...

767 ANTI–MA2-ASSOCIATED ENCEPHALITIS IS AN AUTOIMMUNE PARANEOPLASTIC DISORDER USUALLY ASSOCIATED WITH TESTICULAR CANCER. PATIENTS PRESENT with symptoms of brainstem, limbic, and hypothalamic impairment, such as eye movement abnormalities, memory loss, and endocrine dysfunction.1 In addition, some patients may develop narcoleptic features such as hypersomnia and cataplexy due to hypocretin-1 def...

Authors of earlier studies examined the epidemiological characteristics of certain eye diseases: age-related macular degeneration (AMD), refractive errors and glaucoma in the area of Primorsho-goranska County (the island of Rab, Novi Vinodolshi and Delnice). It was found that the occurrence of AMD is most common on the island of Rab, followed by Novi Vinodolski and it is least common in Gorshi ...

In recent years, huge investigations on cancer progression and invasion have led to under-stand the pivotal role of tumor microenvironment. The current era of cancer therapy is based on the concept of simply targeting precise mechanisms to kill or to suppress the growth and expansion of malignant cells. Clinical data clearly correlate with in-vitro re-sults, emphasizing the direct impact of can...

PURPOSE: To relate the finding of selecti ve enhancement of different turns of the cochlea to the frequency range of the hearing loss measured by audiogram . METHODS: Six patients aged 23 to 53 years, four men and two women, who presented w ith sudden hearing loss and had segmental enhancement of different turns of the cochlea on contrast-enhanced MR imaging were included in this retrospective ...

Mast cells represent a potential source of interleukin-6 (ILlenge with SCF, bone marrow-derived cultured mouse mast 6) and other cytokines that have been implicated in host cells (BMCMCs) released amounts of IL-6 that were greater defense, tissue maintenance/remodeling, immunoregulathan 100-fold more than those produced by unstimulated tion, and many other biologic responses. In acquired imcell...

Helicobacter pylori infects more than 50% of the world population and is acquired in infan‐ cy. Higher prevalence is found in developing countries, and within geographic areas the predominance correlates inversely with socioeconomic status, especially with living con‐ ditions during childhood. Initially, in adults, H. pylori was only associated with gastric diseases, such as peptic ulcer, gastr...

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive disease with an average surviving time of 3 to 5 years. The hallmarks of the pathological changes are loss of lower motor neurons in the spinal cord and upper motor neurons(UMN) in the motor cortex. However, structural MRI studies of the spinal cord and the brain often fail to show any changes. Due to lack of objective and quantitativ...

SUMMARY Neuromuscular junction ultrastructure in rat forelimb digit extensor muscle (FDE), extensor digitorum longus (EDL) and soleus (SOL) was quantitatively investigated in experimental autoim-mune myasthenia gravis (EAMG). Experimental animals were immunized with highly purified Narke Japonica acetylcholine receptor protein plus complete Freund's adjuvant and B. pertussis vaccine : control a...