Computing a template in the Large Deformation Diffeomorphic Metric Mapping (LDDMM) framework is a key step for the study of large databases of anatomical surfaces, but can lead to very computationally expensive algorithms in the case of large databases. Here we present an iterative method to compute a better initialization for the template estimation method proposed in [1]. The method provides ...

Time-to-contact (TTC) estimation is beneficial for visual navigation. It can be estimated from an image projection, either in a camera or on the retina, by looking at the rate of expansion of an object. When expansion rate (E) is properly defined, TTC = 1/E. Primate dorsal MST cells have receptive field structures suited to the estimation of expansion and TTC. However, the role of MST cells in ...

The statistical method of motor unit number estimation (MUNE) uses the natural stochastic variation in a muscle’s compound response to electrical stimulation to obtain an estimate of the number of recruitable motor units. The current method assumes that this variation follows a Poisson distribution. We present an alternative that instead assumes a binomial distribution. Results of computer simu...

Mupirocin (MUP) is an effective topical antibiotic with poor skin permeability; however, its permeability can be improved by a nanoemulsion formulation based on eucalyptus oil or eucalyptol. Despite this improvement, the has limitations, such as low viscosity, spreadability, and retention skin. To overcome these aim of study was to develop nanoemulgel that would enhance rheological behaviour ph...

Surface EMG (SEMG) is little used for diagnostic purposes in clinical neurophysiology, mainly because it provides little direct information on individual motor units (MUs). One of the techniques to estimate the MU size is intra-muscular Macro EMG. The present study compares SEMG with Macro EMG. Fifty-eight channel SEMG was recorded simultaneously with Macro EMG. Individual MUPs were obtained by...

There is an agreement that perceived usability is important beyond actual effectiveness of software systems. Perceived usability is often obtained by self-reports provided after system use. Aiming to improve summative usability testing, we propose a methodology to enhance in-depth testing of users' performance and perceived usability at the task level. The metacognitive research approach allows...

BACKGROUND Novel policy interventions may lack evaluation-based evidence. Considerations to introduce minimum unit pricing (MUP) of alcohol in the UK were informed by econometric modelling (the 'Sheffield model'). We aim to investigate policy stakeholders' views of the utility of modelling studies for public health policy. METHODS In-depth qualitative interviews with 36 individuals involved i...

Many medical image analysis problems that involve multimodal images lend themselves to solutions that involve class posterior density function images. This paper presents a method for large deformation exemplar class posterior density template estimation. This method generates a representative anatomical template from an arbitrary number of topologically similar multi-modal image sets using lar...

Templates play a fundamental role in Computational Anatomy. In this paper, we present a Bayesian model for template estimation. It is assumed that observed images I(1), I(2),...,I(N) are generated by shooting the template J through Gaussian distributed random initial momenta theta(1), theta(2),...,theta(N). The template is J modeled as a deformation from a given hypertemplate J(0) with initial ...

Cooperation between relatives yields important fitness benefits, but genetic loci that allow recognition of unfamiliar kin have proven elusive. Sharing of kinship markers must correlate strongly with genome-wide similarity, creating a special challenge to identify specific loci used independently of other shared loci. Two highly polymorphic gene complexes, detected through scent, have been impl...