High-grade gliomas are aggressive and abundantly vascular tumors, and as in most cancer types, blood vessels in advanced lesions are highly abnormal. Poor perfusion and vascular leakage in tumor tissue resulting in hypoxia, necrosis, and high interstitial fluid pressure can hamper the efficient delivery of chemotherapy. Tumor angiogenesis is known to be supported by host leukocytes recruited to...

Introduction: The muscle dysmorphia (DYSMUS) is a psychiatric syndrome that occurs to both genders with higher prevalence in men, in which the individual perceives his body as small and weak when in fact it is strong and muscular. There are no anthropometric approaches in literature about DYSMUS. Objective: To obtain data from a reference population in order to suggest an anthropometric criteri...

Altered nuclear shape is a defining feature of cancer cells. The mechanisms underlying nuclear dysmorphia in cancer remain poorly understood. Here we identify PPP1R12A and PPP1CB, two subunits of the myosin phosphatase complex that antagonizes actomyosin contractility, as proteins safeguarding nuclear integrity. Loss of PPP1R12A or PPP1CB causes nuclear fragmentation, nuclear envelope rupture, ...

In recent years, psychological issues in body-building have received much research attention. 1–4 Given both the popularity of training with weights and the many interesting psychological issues surrounding this phenomenon , research on such issues is clearly warranted. We were pleased therefore to see a recent study by Pickett et al 5 in this journal purporting to examine muscle dysmorphia and...

BACKGROUND Muscle dysmorphia (MD) describes a condition characterised by a misconstrued body image in which individuals who interpret their body size as both small or weak even though they may look normal or highly muscular.MD has been conceptualized as a type of body dysmorphic disorder, an eating disorder, and obsessive–compulsive disorder symptomatology. METHOD AND AIM: Through a review of t...

Objective Although research on muscle dysmorphia (MD), a body dysmorphic disorder subtype, has recently increased, the causes and mechanisms underlying this disorder remain unclear. Results from studies examining disorders associated with body image suggest the involvement of self-schema in biasing attention toward specific body information. The present study examined whether individuals at hig...