Xu S, Pratt SJ, Spangenburg EE, Lovering RM. Early metabolic changes measured by H MRS in healthy and dystrophic muscle after injury. J Appl Physiol 113: 808–816, 2012. First published June 28, 2012; doi:10.1152/japplphysiol.00530.2012.—Skeletal muscle injury is often assessed by clinical findings (history, pain, tenderness, strength loss), by imaging, or by invasive techniques. The purpose of ...

Androgen hormones serve a variety of roles, including determining and maintaining sexual traits. The effects Anabolic Steroids (AAS) like oxandrolone on body composition muscle mass development are intriguing. We provide case 38-year-old woman who was treated with for multiple fractures current right ischiotibial injury, indicating that androgen steroid medication may aid in the recovery bone t...

BACKGROUND Muscle contusions are a common type of muscle injury and are frequently encountered in athletes and military personnel. Although these injuries are capable of healing in most instances, incomplete functional recovery often occurs because of the development of fibrosis in the muscle. We hypothesized that a combination of platelet-rich plasma (PRP) injection and oral administration of ...

INTRODUCTION The injury caused by reperfusion of ischemic skeletal muscle is mediated by the membrane attack complex of complement (C) . This C activation results from local classical pathway activation after deposition of IgM in injured muscle, an event analogous to C deposition in the mucosa of the gut during reperfusion . Our past analysis has indicated that the injury is not uniform even wi...

A recent study describing unique effects of myostatin inhibition on a severely dystrophic (mdx) muscle, and independent experiments showing that branched fibers are uniquely sensitive to activity-induced membrane rupture, have led new hypothesis pathogenesis. This states the absence dystrophin directly results in some degree unrestrained satellite cell activation is not dependent upon prior fib...

BACKGROUND Muscle injury is common and is thought to account for 10%-50% of all sports-related injuries. The use of rest, ice, compression, and elevation is common in clinical practice, but many treatments over a long period are required to produce a therapeutic effect. We evaluated the utility of photodynamic therapy as a new treatment option for the acute stage of muscle injury. METHODS Twe...

The influence of icing on muscle regeneration after crush injury was examined in the rat extensor digitorum longus. After the injury, animals were randomly divided into nonicing and icing groups. In the latter, ice packs were applied for 20 min. Due to the icing, degeneration of the necrotic muscle fibers and differentiation of satellite cells at early stages of regeneration were retarded by ∼1...

INTRODUCTION Acute muscle injury is one of the commonest injuries that often result in loss of training and competition time. The best management for muscle injury has not been identified. Sports medicine practitioners used several approaches in attempt to accelerate time to recovery from muscle injury. More recently growing interest focussed on autologous blood product injection. METHODS A l...

Eccentric contractions (ECs), in which a muscle is forced to lengthen while activated, result in muscle injury and, eventually, muscle strengthening and prevention of further injury. Although the mechanical basis of EC-induced injury has been studied in detail, the biological response of muscle is less well characterized. This study presents the development of a minimally invasive model of EC i...

Muscle strain injuries are some of the most frequent injuries in sports and command a great deal of attention in an effort to understand their etiology. These injuries may be the culmination of a series of subcellular events accumulated through repetitive lengthening (eccentric) contractions during exercise, and they may be influenced by a variety of variables including fiber strain magnitude, ...