نتایج جستجو برای: mutagen x
تعداد نتایج: 624698 فیلتر نتایج به سال:
Arsenite, the trivalent form of arsenic present in the environment, is a known human carcinogen that lacked mutagenic activity in bacterial and standard mammalian cell mutation assays. We show herein that when evaluated in an assay (AL cell assay), in which both intragenic and multilocus mutations are detectable, that arsenite is in fact a strong dose-dependent mutagen and that it induces mostl...
Optimal conditions, defined by the use of a known auxotrophic strain, are described for the mutagenesis of Coprinus Zagopus oidia by N-methyl-N’nitro-N-nitrosoguanidine (NTG), which is a very effective mutagen for bacteria and yeast. The oidia were best treated in phosphate buffer (PH 6.8) with a concentration of 15 pg. NTG/ml. for about 70 min. The yield of auxotrophs was considerably less tha...
Mutagen challenge and DNA repair assays have been used in case-control studies for nearly three decades to assess human cancer risk. The findings still engender controversy because blood was drawn after cancer diagnosis so the results may be biased, a type called 'reverse causation'. We therefore used Epstein-Barr virus-transformed lymphoblastoid cell lines established from prospectively collec...
The strain employed was S288C, a genetically well-studied respiration-sufficient haploid that forms predominantly single cells and cells with one bud during log-phase growth and single cells in stationary phase. The respiratory genetic makeup of spontaneous and induced petites was determined by tetrad analysis and by complementation tests (PITTMAN et al. 1960; SHERMAN and EPHRUSSI 1962) using s...
The Amazonian Croton lechleri stem bark essential oil was tested for its anti-mutagenic potential by performing the Ames test against heterocyclic amines (HCAs), in continuing research on applicative functional profile of this phytocomplex as food ingredient (Rossi et al., 2011). Salmonella typhimurium strain TA98 was used with and without metabolic activation (S9 mix). The anti-mutagenic prope...
OBJECTIVE To analyze and compare components of the 3 primary DNA repair pathways of Epstein-Barr virus-transformed lymphocyte (lymphoblastoid) cell lines derived from 9 patients with squamous cell carcinoma of the head and neck and 11 cancer-free controls. These cell lines were previously characterized by using an established cytogenetic marker of cancer susceptibility (mutagen sensitivity assa...
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