OBJECTIVES This study was designed to determine the relationship between baseline white blood cell (WBC) count and angiographic and clinical outcomes in patients with unstable angina (UA)/non–ST-segment elevation myocardial infarction (NSTEMI) and to see if WBC count was a significant predictor of outcomes independent of other biomarkers. BACKGROUND Inflammation has been shown to play a role in...

BACKGROUND In acute coronary syndromes, C-reactive protein (CRP) strongly relates to subsequent death, but surprisingly not to recurrent myocardial infarction. Other biomarkers may reflect different processes related to these outcomes. We assessed 8 inflammatory and vascular biomarkers and the risk of death and recurrent nonfatal cardiovascular events in the 16 weeks after an acute coronary syn...

OBJECTIVES To test the hypothesis that cardiac-enriched micro-RNAs can serve as accurate biomarkers that reflect myocardial injury and to predict the postoperative course following pediatric cardiac surgery. Micro-RNAs have emerged as plasma biomarkers for many pathologic states. We aimed to quantify preoperative and postoperative plasma levels of cardiac-enriched micro-RNA-208a, -208b, and -49...

BACKGROUND In spite of great advances in target-oriented Western medicine for treating myocardial infarction (MI), it is still a leading cause of death in a worldwide epidemic. In contrast to Western medicine, Traditional Chinese medicine (TCM) uses a holistic and synergistic approach to restore the balance of Yin-Yang of body energy so the body's normal function can be restored. Sini decoction...

Stratification of cardiac patients arriving at the emergency department is now being made according to the levels of acute cardiac biomarkers (i.e. cardiac troponin (cTn) or creatine kinase myocardial band (CK-MB)). Ongoing efforts are undertaken in an attempt to identify and validate additional cardiac biomarkers, for example, interleukin-6, soluble CD40L, and C-reactive protein, in order to f...

Cardiac biomarkers such as CK-MB, troponins, and myoglobin provide the basis for the diagnosis of acute myocardial infarction (AMI) through identifi cation of the necrosis of myocardial cells in the heart. For emergency physicians, or any clinician evaluating and treating patients presenting to the hospital with acute coronary syndrome (ACS), ischemic changes on the 12-lead electrocardiogram or...

Background CMR is a useful tool for myocardial tissue characterization and to assess fibrosis and edema non-invasively. The estimation of extracellular volume fraction (ECV) is emerging as accurate biomarkers in many cardiac diseases associated with diffuse myocardial fibrosis. In this work, we present our automatic tool for ECV map creation. All the computational system consists of an executab...

several studies have reported that the antioxidant properties of melatonin can provide cardiac protection through scavenging of free radicals. this study sought to investigate the efficacy of melatonin on cardiac biomarkers, myocardial-specific protein high sensitive troponin-t (hs-tnt) and creatine kinase-mb (ck-mb), in patients with st-segment elevation myocardial infarction (stemi) undergoin...