We consider a finite-horizon, periodic-review inventory model with demand forecasting updates following the martingale model of forecast evolution (MMFE). The optimal policy is a state-dependent base-stock policy, which, however, is computationally intractable to obtain. We develop tractable bounds on the optimal base-stock levels and use them to devise a general class of heuristic solutions. T...

Problem definition : We examine a dynamic assignment problem faced by large wireless service provider (WSP) that is Fortune 100 company. This company manages two warranties: (i) customer warranty the WSP offers its customers and (ii) an original equipment manufacturer (OEM) OEMs offer WSP. The uses devices refurbished OEM as replacement devices, hence their operation closed-loop supply chain. D...

Mammalian cancers depend on "multiple hits," some of which promote growth and some of which block apoptosis. We screened for mutations that require a synergistic block in apoptosis to promote tissue overgrowth and identified myopic (mop), the Drosophila homolog of the candidate tumor-suppressor and endosomal regulator His-domain protein tyrosine phosphatase (HD-PTP). We find that Myopic regulat...

purpose: to evaluate the efficacy, safety, predictability and stability of implantable collamer lens (icl) and toric icl for the treat­ment of high myopia and high myopic astigmatism, one year prospective study. methods: in this prospective nonrandomized clinical trial, 95 eyes of 51 patients that had icl (31 eyes) and toric icl (64 eyes) were participate in eye research center, department of o...

PURPOSE This study was performed to first investigate the morphological differences in the optic nerve head between highly myopic non-glaucomatous controls and highly myopic glaucomatous eyes in comparison with the differences between emmetropic non-glaucomatous controls and emmetropic glaucomatous eyes using confocal scanning laser ophthalmoscopy. Further, the ability of the apparatus in glauc...

AIMS To determine the incidence and predisposing findings for choroidal neovascularisation (CNV) in a large series of highly myopic patients. METHODS The medical records of 218 consecutive patients (325 eyes) with myopic fundus changes in the macula were reviewed. The incidence of CNV during a follow up of at least 3 years of highly myopic patients and identification of predisposing findings ...