Plants, bacteria and some fungi are known to produce indole-3-acetic acid (IAA) by employing various pathways. Among these pathways, the indole-3-pyruvic acid (IPA) pathway is the best studied in green plants and plant-associated beneficial microbes. While IAA production circuitry in plants has been studied for decades, little is known regarding the IAA biosynthesis pathway in fungal species. H...

Recently, we have demonstrated that N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652) (1) adopts a bitopic pose at one protomer of a dopamine D2 receptor (D2R) dimer to negatively modulate the binding of dopamine at the other protomer. The 1H-indole-2-carboxamide moiety of 1 extends into a secondary pocket between the extracellular end...

In the title compound, C27H22N2O4, the two indole ring systems are approximately perpendicular to each other, with a dihedral angle of 84.5 (5)° between their planes; the benzene ring is twisted with respect to the two indole ring systems at angles of 78.5 (5) and 86.5 (3)°. In the crystal, mol-ecules are linked by N-H⋯O hydrogen bonds, weak C-H⋯O and C-H⋯N hydrogen bonds, and C-H⋯π inter-actio...

In the title mol-ecule, C(24)H(17)N(3)O, the mean plane of the indolone ring forms dihedral angles of 112.0 (1) and 103.1 (1)° with the planes of the two indole rings. The dihedral angle between the mean planes of the two indole rings is 63.5 (1)°. In the crystal structure, mol-ecules are linked via inter-molecular N-H⋯O hydrogen bonds, forming a two-dimensional network parallel to the ab plane.

In the title compound, C(29)H(26)N(2)O(4), the benzene ring is twisted by 73.5 (5) and 84.9 (3)° with respect to the mean planes of the two indole ring systems; the mean planes of the indole ring systems are oriented at a dihedral angle of 82.0 (5)°. In the crystal, mol-ecules are linked by pairs of N-H⋯O hydrogen bonds into chains.

In the title compound, C(23)H(22)ClN(3)O, the benzene ring of the 4-chorobenzyl group makes a dihedral angle of 78.56 (6)° with the best plane of the indole ring. The double bond connecting the aza-bicyclic and indole groups adopts a Z geometry. The geometry adopted by the C=N bond with respect to the N-OH bond is trans. The absolute configuration of the compound was determined from refinement ...

In the title mol-ecule, C(13)H(16)N(2)O(2)S, the nine non-H atoms comprising the indole residue are approximately coplanar (r.m.s. deviation = 0.031 Å). The partially saturated ring adopts a chair conformation. One amine H forms an inter-molecular N-H⋯O hydrogen bond to a sulfonamide O atom, while the other amine H form is connected to the indole N atom of an adjacent mol-ecule via an N-H⋯N hyd...

An indole hydrazone has successfully been synthesized employing Schiff base reaction conditions starting from 4,6-dimethoxy-2,3-diphenylindole-7-carbaldehyde with hydrazine hydrate. The of this compound acetone yielded based imine compound. structure targeted was identified by mass and 1H spectroscopy along single crystal X-ray diffraction technique. Also, bromination bis-indole N-bromo succini...

A variety of intercellular signal molecules, such as, the most studied N-acyl-homoserinelactones (AHLs) in Gram-negative bacteria, autoinducer (AI-2) in both Gram-negative and Gram-positive bacteria, and signal peptides in Gram-positive bacteria, have been discovered over the last 20 years. Although it has been known for over 100 years that many bacteria produce indole, the real biological role...

Depending on the catalyst used, N-methylation of indole with dimethylcarbonate (DMC)—an environmentally friendly alkylation agent—yields different products. With 1,4-diazabicyclo[2.2.2]octane (DABCO), reaction forms only N-methylated indole, but 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), both and N-methoxycarbonylated are formed. Using direct ESI(+)-MS monitoring to collect actual snapshots chan...